ArticleDiagnostics (Basel, Switzerland)2021
Sex Difference in the Risk of Dementia in Patients with Atrial Fibrillation.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Quantifying the association between stroke and dementia: a bibliometric study.Frontiers in neurology · 2024Pooled it
- Atrial Fibrillation and the Risk of Early-Onset Dementia: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2022Pooled it
- Hormonal Atrial Fibrillation: Pathophysiological Mechanisms That Trigger and Sustain the Arrhythmic Circuits.Biomedicines · 2025Review
- Temporal Trends in the Association Between Female Sex and Ischemic Stroke Among Patients With Atrial Fibrillation.Journal of the American Heart Association · 2025Article
- The role of atrial fibrillation in vascular cognitive impairment and dementia: epidemiology, pathophysiology, and preventive strategies.GeroScience · 2025Review
- Age at Diagnosis of Atrial Fibrillation and Incident Dementia.JAMA network open · 2023Article
- Discovery ofBiology · 2023Article
- Ablation of atrial fibrillation and dementia risk reduction during long-term follow-up: a nationwide population-based study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Utility of short-term telemetry heart rhythm monitoring and CHAWorld journal of cardiology · 2023Article
- Atrial fibrillation as a contributor to the mortality in patients with dementia: A nationwide cohort study.Frontiers in cardiovascular medicine · 2023Article
- Association between multimorbidity status and incident dementia: a prospective cohort study of 245,483 participants.Translational psychiatry · 2022Article
- Revealing the Influences of Sex Hormones and Sex Differences in Atrial Fibrillation and Vascular Cognitive Impairment.International journal of molecular sciences · 2021Review
- Predictors of dementia amongst newly diagnosed non-valvular atrial fibrillation patients.Indian heart journalObservational
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrial fibrillation (AF) is one of the risk factors for dementia. Female sex is an inconsistent risk factor for dementia after adjusting for age in the general population, and there lacks research on its impact in developing dementia in patients with AF. This paper aims to investigate whether female sex is a risk factor for dementia in AF patients. Data of patients with newly diagnosed AF between 2001-2013 were retrieved from Taiwan's National Health Insurance Research Database. Exclusion criteria were: patients with incomplete demographic data, age < 20 years, rheumatic heart disease, hyperthyroidism, past valvular heart surgery, and a history of dementia. Propensity score matching (PSM) between sexes was performed, including comorbidities, medications and index date stratified by age. The primary outcome was a new diagnosis of dementia at follow-up. A total of 117,517 men and 156,705 women were eligible for analysis. After 1:1 PSM, both 100,065 men and women (aged 72.5 ± 12.5 years) were included for analysis. Dementia risk varied with age in women compared with men. The difference was negligible for ≤55 years (sub distribution HR (SHR) = 0.89, 95% CI 0.73-1.07), but increased between 56-65 years (SHR = 1.13, 95% CI 1.02-1.25), 66-75 years (SHR = 1.14, 95% CI 1.09-1.20), 75-85 years (SHR = 1.11, 95% CI 1.07-1.15) and >85 years (SHR 1.10, 95% CI 1.04-1.16) for females. This study establishes that female sex increases the risk of developing dementia compared to male sex in AF patients aged >56 years. However, the impact of female sex on dementia in AF patients differs between dementia types.
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