Evidence map›Paper›PMID 33922775›Full record

ArticleJournal of clinical medicine2021

Appropriate ICD Interventions for Ventricular Arrhythmias Are Predicted by Higher Syntax Scores I and II in Patients with Ischemic Heart Disease.

Teresa Strisciuglio, Giuseppe Ammirati, Valerio Pergola, Lucio Addeo, Maria Angela Losi, Aniello Viggiano, Livio Imparato, Vincenzo Russo, Enrico Melillo, Gerardo Nigro and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Incidence and risk factors for first and recurrent ICD shock therapy in patients with an implantable cardioverter defibrillator.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Teresa StrisciuglioDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Giuseppe AmmiratiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-7440-1793
Valerio PergolaDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Lucio AddeoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Maria Angela LosiDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Aniello ViggianoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Livio ImparatoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Vincenzo RussoDepartment of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0002-9227-0360
Enrico MelilloDepartment of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Gerardo NigroDepartment of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.ORCID 0000-0003-1776-8449
Giuseppe StabileDepartment of Cardiology, Clinica Montervergine, 83013 Mercogliano, Italy.ORCID 0000-0003-4646-0865
Antonio D'OnofrioDepartment of Medical Translational Sciences, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy.
Giovanni EspositoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Antonio RapacciuoloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.ORCID 0000-0002-4739-7004
University of Naples Federico II · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe occurrence of ventricular arrhythmias (VAs) in ischemic heart disease (IHD) patients is related to the presence and extent of fibrotic/scar tissue. As coronary atherosclerosis is the underlying cause of myocardial ischemia and fibrosis, in IHD patients implanted with an implantable cardioverter defibrillator (ICD) we investigated the relation between the VA burden and the complexity of coronary atherosclerotic lesions. METHODS AND

resultsIn IHD patients who underwent coronary angiography and ICD implant, the Syntax scores I and II (SSI-II), as index of the severity of the coronary atherosclerotic disease, and the occurrence of VA were assessed. Overall 144 patients were included (123 males). Of these 22 patients (15%) experienced at least one episode of VA (cycle length 298 ± 19 msec) that required ICD intervention. The number of episodes per patient and per year was 4 ± 6 and 2.8 ± 4, respectively. Patients that experienced a VA compared to those free from arrhythmic events did not have distinct baseline clinical characteristics except for a higher SS I and SS II (21 (IQR 13-38) vs. 16 (IQR 10-23);

conclusionHigher SS I-II scores reflect a more severe coronary atherosclerosis and are associated with a greater VA burden. Further studies are needed to better clarify the ability of SSI-II to stratify the risk of IHD patients to develop life-threatening VA.

Indexed as

coronary artery diseaseheart failureimplantable cardiac defibrillatorventricular arrhythmias

Identifiers

PMID33922775
PMCPMC8123075
OpenAlexW3157744522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.