Evidence map›Paper›PMID 33922739›Full record

ArticlePharmaceutics2021

Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery.

Esra Altun, Esra Yuca, Nazmi Ekren, Deepak M Kalaskar, Denisa Ficai, Georgiana Dolete, Anton Ficai, Oguzhan Gunduz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Comparison of In Vitro andTurkish journal of pharmaceutical sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esra AltunCentre for Nanotechnology & Biomaterials Research, Department of Metallurgical and Materials Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, Turkey.
Esra YucaDepartment of Molecular Biology and Genetics, Faculty of Arts and Sciences, Davutpasa Campus, Yildiz Technical University, Istanbul 34220, Turkey.
Nazmi EkrenCentre for Nanotechnology & Biomaterials Research, Department of Electrical-Electronics Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, Turkey.
Deepak M KalaskarUCL Division of Surgery and Interventional Science, Royal Free Hospital Campus, University College London, Rowland Hill Street, London NW3 2PF, UK.ORCID 0000-0002-0576-1816
Denisa FicaiDepartment of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania.ORCID 0000-0003-1243-6904
Georgiana DoleteNational Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania.
Anton FicaiNational Centre for Micro- and Nanomaterials, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania.ORCID 0000-0002-1777-0525
Oguzhan GunduzCentre for Nanotechnology & Biomaterials Research, Department of Metallurgical and Materials Engineering, Faculty of Technology, Goztepe Campus, Marmara University, Istanbul 34722, Turkey.ORCID 0000-0002-9427-7574

Funding

Marmara University FEN-C-YLP-110117-0021UKIERI IND/CONT/G/17-18/46
6 · The paper itself

Abstract

This study investigates the usage of electrohydrodynamic (EHD)-3D printing for the fabrication of bacterial cellulose (BC)/polycaprolactone (PCL) patches loaded with different antibiotics (amoxicillin (AMX), ampicillin (AMP), and kanamycin (KAN)) for transdermal delivery. The composite patches demonstrated facilitated drug loading and encapsulation efficiency of drugs along with extended drug release profiles. Release curves were also subjected to model fitting, and it was found that drug release was optimally adapted to the Higuchi square root model for each drug. They performed a time-dependent and diffusion-controlled release from the patches and followed Fick's diffusion law by the Korsmeyer-Peppas energy law equation. Moreover, produced patches demonstrated excellent antimicrobial activity against Gram-positive (

Indexed as

antibiotic patchesbacterial cellulosedrug releaseelectrohydrodynamic printingpolymer

Identifiers

PMID33922739
PMCPMC8145298

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.