Evidence map›Paper›PMID 33922732›Full record

ArticleViruses2021

Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.

Mohammad Alkhatib, Velia Chiara Di Maio, Valentina De Murtas, Ennio Polilli, Martina Milana, Elisabetta Teti, Gianluca Fiorentino, Vincenza Calvaruso, Silvia Barbaliscia, Ada Bertoli and 20 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 8 institutions in 1 country.

Mohammad AlkhatibDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Velia Chiara Di MaioDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Valentina De MurtasDepartment of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-6284-3076
Ennio PolilliInfectious Diseases Unit, Pescara General Hospital, 65124 Pescara, Italy.
Martina MilanaHepatology Unit, University Hospital of Rome "Tor Vergata", 00133 Rome, Italy.
Elisabetta TetiInfectious Diseases Unit, University Hospital of Rome "Tor Vergata", 00133 Rome, Italy.
Gianluca FiorentinoInfectious Diseases Unit, Sant'Andrea Hospital-"Sapienza" University, 00189 Rome, Italy.
Vincenza CalvarusoGastroenterology, "P. Giaccone" University Hospital, 90127 Palermo, Italy.
Silvia BarbalisciaDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Ada BertoliDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Rossana ScutariDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Luca CariotiDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Valeria CentoDepartment of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy.
Maria Mercedes SantoroDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Alessandro OrroITB-CNR, Institute of Biomedical Technologies, National Research Council of Italy, 20090 Milan, Italy.ORCID 0000-0002-2581-9579
Ivana MaidaDepartment of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.
Ilaria LenciHepatology Unit, University Hospital of Rome "Tor Vergata", 00133 Rome, Italy.
Loredana SarmatiInfectious Diseases Unit, University Hospital of Rome "Tor Vergata", 00133 Rome, Italy.ORCID 0000-0003-1452-0333
Antonio CraxìGastroenterology, "P. Giaccone" University Hospital, 90127 Palermo, Italy.
Caterina PasquazziInfectious Diseases Unit, Sant'Andrea Hospital-"Sapienza" University, 00189 Rome, Italy.
Giustino ParrutiInfectious Diseases Unit, Pescara General Hospital, 65124 Pescara, Italy.
Sergio BabudieriDepartment of Clinical and Experimental Medicine, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-7291-8687
Luciano MilanesiITB-CNR, Institute of Biomedical Technologies, National Research Council of Italy, 20090 Milan, Italy.ORCID 0000-0002-1201-3939
Massimo AndreoniInfectious Diseases Unit, University Hospital of Rome "Tor Vergata", 00133 Rome, Italy.
Mario AngelicoHepatology Unit, University Hospital of Rome "Tor Vergata", 00133 Rome, Italy.
Carlo Federico PernoDepartment of Diagnostic and Laboratory Medicine, IRCCS Bambino Gesu', Pediatric Hospital, 60165 Rome, Italy.
Francesca Ceccherini-SilbersteinDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Valentina SvicherDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Romina SalpiniDepartment of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
On Behalf Of Hirma Hepatocarcinoma Innovative Research MArkers And Fondazione Vironet C Hcv Virology Italian Resistance
University of Rome Tor Vergata · ITUniversity of Sassari · ITAzienda Ospedaliera Sant'Andrea · ITAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITAzienda USL di Pescara · ITInstitute of Biomedical Technologies · ITBambino Gesù Children's Hospital · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%,

Indexed as

GenotypeAgedBiomarkersCarcinoma, HepatocellularDisease SusceptibilityFemaleHepacivirusHepatitis CHost-Pathogen InteractionsHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedMutationRNA-Dependent RNA PolymeraseBiomarkersNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseViral Nonstructural Proteinscirrhosisgenetic variabilitygenotype 1bhepatitis C virushepatocellular carcinomaNS5A

Identifiers

PMID33922732
PMCPMC8146897
OpenAlexW3159344124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.