Evidence map›Paper›PMID 33922629›Full record

ArticleBiomedicines2021

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Jorge Gallego-Valle, Sergio Gil-Manso, Ana Pita, Esther Bernaldo-de-Quirós, Rocío López-Esteban, Marta Martínez-Bonet, Verónica Astrid Pérez-Fernández, Ramón Pérez-Caballero, Carlos Pardo, Juan-Miguel Gil-Jaurena and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Jorge Gallego-ValleLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.ORCID 0000-0002-1603-1720
Sergio Gil-MansoLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.ORCID 0000-0003-2480-3628
Ana PitaPediatric Cardiac Surgery Unit (HGUGM), Hospital Materno Infantil del Hospital General Universitario Gregorio Marañón, c/O'Donnell, 48, 28009 Madrid, Spain.
Esther Bernaldo-de-QuirósLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.ORCID 0000-0001-8470-9882
Rocío López-EstebanLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.
Marta Martínez-BonetLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.ORCID 0000-0003-0715-403X
Verónica Astrid Pérez-FernándezLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.
Ramón Pérez-CaballeroPediatric Cardiac Surgery Unit (HGUGM), Hospital Materno Infantil del Hospital General Universitario Gregorio Marañón, c/O'Donnell, 48, 28009 Madrid, Spain.
Carlos PardoPediatric Cardiac Surgery Unit (HGUGM), Hospital Materno Infantil del Hospital General Universitario Gregorio Marañón, c/O'Donnell, 48, 28009 Madrid, Spain.
Juan-Miguel Gil-JaurenaPediatric Cardiac Surgery Unit (HGUGM), Hospital Materno Infantil del Hospital General Universitario Gregorio Marañón, c/O'Donnell, 48, 28009 Madrid, Spain.
Rafael Correa-RochaLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.ORCID 0000-0003-3456-9986
Marjorie PionLaboratory of Immune-Regulation, Gregorio Marañón Health Research Institute (IiSGM), Hospital General Gregorio Marañon, c/Dr. Esquerdo, 46, 28007 Madrid, Spain.ORCID 0000-0002-6406-747X
Hospital General Universitario Gregorio Marañón · ES

Funding

Fundacion Familia Alonso FFA-FIBHGM-2019IiSGM Intramural Grants PI-MP-2018IiSGM Intramural Grants Pre-JGV-2018Instituto de Salud Carlos III, ERDF Funds from the European commission "A way of making Europe" PI18/00495, DTS18/00038, PI18/00495Madrid community grants, ERDF Funds from the European commission "A way of making Europe" B2017/BMD3727Youth Employment Program of Madrid community grants, ERDF Funds from the European commission "A way of making Europe" PEJD-2018-PRE/BMD-809
6 · The paper itself

Abstract

Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce tolerance and are regulators of immune homeostasis. Natural Treg cells (nTregs), described as CD4

Indexed as

engineering cellsFOXP3human thymocytesregulatory T cells

Identifiers

PMID33922629
PMCPMC8146103
OpenAlexW3158779104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.