Evidence map›Paper›PMID 33922589›Full record

ArticleMolecules (Basel, Switzerland)2021

Isomaltulose Exhibits Prebiotic Activity, and Modulates Gut Microbiota, the Production of Short Chain Fatty Acids, and Secondary Bile Acids in Rats.

Zhan-Dong Yang, Yi-Shan Guo, Jun-Sheng Huang, Ya-Fei Gao, Fei Peng, Ri-Yi Xu, Hui-Hui Su, Ping-Jun Zhang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  3. Longitudinal associations between PMFrontiers in cellular and infection microbiology · 2026
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  5. Pharmaceutics · 2025
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  7. Review
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  10. Review
  11. Frontiers in nutrition · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Isomelezitose Overproduction by Alginate-Entrapped RecombinantInternational journal of molecular sciences · 2022
    Article
  17. Article
  18. Frontiers in veterinary science · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Zhan-Dong YangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Yi-Shan GuoGuangdong Engineering Lab of High Value Utilization of Biomass, Institute of Bioengineering, Guangdong Academy of Sciences, Guangzhou 510316, China.
Jun-Sheng HuangGuangdong Engineering Lab of High Value Utilization of Biomass, Institute of Bioengineering, Guangdong Academy of Sciences, Guangzhou 510316, China.
Ya-Fei GaoGuangdong Engineering Lab of High Value Utilization of Biomass, Institute of Bioengineering, Guangdong Academy of Sciences, Guangzhou 510316, China.
Fei PengSchool of Food Science and Engineering, Nanchang University, Nanchang 330000, China.ORCID 0000-0001-5370-8676
Ri-Yi XuGuangdong Engineering Lab of High Value Utilization of Biomass, Institute of Bioengineering, Guangdong Academy of Sciences, Guangzhou 510316, China.
Hui-Hui SuGuangdong Engineering Lab of High Value Utilization of Biomass, Institute of Bioengineering, Guangdong Academy of Sciences, Guangzhou 510316, China.ORCID 0000-0003-3654-9364
Ping-Jun ZhangGuangdong Engineering Lab of High Value Utilization of Biomass, Institute of Bioengineering, Guangdong Academy of Sciences, Guangzhou 510316, China.
Guangdong Academy of Sciences · CNNanchang University · CNSun Yat-sen University · CN

Funding

GDAS' Projection of Science and Technology Development No. 2021GDASYL-20210103037Guangdong Basic and Applied Basic Research Foundation No. 2020A1515110406Opening Project of Guangxi Key Laboratory of Green Processing of Sugar Resources No. GXTZY202008
6 · The paper itself

Abstract

In vitro experiments have indicated prebiotic activity of isomaltulose, which stimulates the growth of probiotics and the production of short chain fatty acids (SCFAs). However, the absence of in vivo trials undermines these results. This study aims to investigate the effect of isomaltulose on composition and functionality of gut microbiota in rats. Twelve Sprague-Dawley rats were divided into two groups: the IsoMTL group was given free access to water containing 10% isomaltulose (

Indexed as

AnimalsBile Acids and SaltsFatty Acids, VolatileGastrointestinal MicrobiomeGlucose Tolerance TestIsomaltoseMaleProbioticsRatsRats, Sprague-DawleyRNA, Ribosomal, 16SBile Acids and SaltsFatty Acids, VolatileIsomaltoseisomaltuloseRNA, Ribosomal, 16Sgut microbiotaisomaltuloseprebioticssecondary bile acidsshort chain fatty acids

Identifiers

PMID33922589
PMCPMC8122910
OpenAlexW3159178963

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.