Evidence map›Paper›PMID 33922473›Full record

ArticleMolecules (Basel, Switzerland)2021

Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol-A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling.

Jakub Jakowiecki, Renata Abel, Urszula Orzeł, Paweł Pasznik, Robert Preissner, Sławomir Filipek

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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  8. Carvone derived cannabidiol enantiomers as novel anticonvulsants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jakub JakowieckiBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02093 Warsaw, Poland.ORCID 0000-0001-5882-1029
Renata AbelStructural Bioinformatics Group, Institute for Physiology, Charité-University Medicine Berlin, 10115 Berlin, Germany.ORCID 0000-0003-0802-8078
Urszula OrzełBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02093 Warsaw, Poland.
Paweł PasznikBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02093 Warsaw, Poland.
Robert PreissnerStructural Bioinformatics Group, Institute for Physiology, Charité-University Medicine Berlin, 10115 Berlin, Germany.ORCID 0000-0002-2407-1087
Sławomir FilipekBiological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, 02093 Warsaw, Poland.ORCID 0000-0003-3147-3858
University of Warsaw · PLCharité - Universitätsmedizin Berlin · DEWroclaw Medical University · PL

Funding

Narodowe Centrum Nauki 2016/23/N/NZ1/02960
6 · The paper itself

Abstract

The CB

Indexed as

Allosteric RegulationAllosteric SiteAnimalsCannabidiolHumansMagnetic Resonance SpectroscopyModels, MolecularMolecular Dynamics SimulationProtein BindingProtein Structure, SecondaryReceptor, Cannabinoid, CB1CannabidiolReceptor, Cannabinoid, CB1allosteric modulationcannabinoid receptorCB1CBDGPCRsinteraction fingerprintsmolecular dynamicsREST2THC

Identifiers

PMID33922473
PMCPMC8122825
OpenAlexW3158369117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.