ReviewMicroorganisms2021
The Impact and Burden of Neurological Sequelae Following Bacterial Meningitis: A Narrative Review.
Review in Microorganisms, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- The epidemiology of infectious meningitis in Ghana: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Clinical outcomes and economic burden of bacterial meningitis in Africa: a protocol for systematic review and meta-analysis.BMJ open · 2026Article
- Global burden shift from infectious to non-communicable neurological disorders in adolescents and young adults (10-24 years): findings from the global burden of disease study 1990-2021.International journal of clinical pharmacy · 2026Article
- Strengthening regional surveillance: MenMap Network's year 1 findings on bacterial meningitis in Jordan, Egypt, and Iraq (2023-2024).IJID regions · 2026Article
- Pathogens of the Human Central Nervous System- the Major Bacterial Pathogens.Molecular neurobiology · 2026Review
- DNA-Templated Silver Nanoclusters Demonstrate Potent Antimicrobial Activity Against the Clinically Relevant Pathogens,ACS applied bio materials · 2026Article
- Crotonylation driving Streptococcus pneumoniae adaption and virulence.Journal of advanced research · 2026Article
- Cranial ultrasound as a diagnostic tool for infant meningitis in a low-or middle income setting: "sensitivity and specificity".Journal of ultrasound · 2026Article
- Corticosteroids as adjunctive therapy in acute meningitis: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Non-invasive meningitis screening in neonates and infants: multicentre international study.Pediatric research · 2026Article
- Pathogen detection in acellular cerebrospinal fluid: diagnostic insights from a pediatric cohort in Colombia.Microbiology spectrum · 2026Observational
- Global Assessment of Health Utilities Associated with Pneumococcal Disease in Adults: Targeted Literature Reviews.PharmacoEconomics - open · 2026Review
- Development and validation of a nomogram for suspected post-neurosurgical bacterial ventriculitis/meningitis.Frontiers in medicine · 2026Article
- Diagnostic comparison of microbial culture and polymerase chain reaction for the diagnosis of bacterial meningitis in a tertiary hospital, North West Ethiopia.IJID regions · 2025Article
- Spatial and Temporal Analysis of Meningitis Cumulative Incidence in Iran, 2011-2022.Iranian journal of public health · 2025Article
- The Evaluation of a Rapid Syndromic Multiplex Meningitis/Encephalitis RT-qPCR MX-17 Panel.Diagnostics (Basel, Switzerland) · 2025Article
- Molecular detection and serotyping of acute bacterial meningitis pathogens in Indian children.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Global Assessment of Health Utilities Associated with Pneumococcal Disease in Children-Targeted Literature Reviews.PharmacoEconomics · 2025Review
- Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model.PLoS biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The burden, impact, and social and economic costs of neurological sequelae following meningitis can be devastating to patients, families and communities. An acute inflammation of the brain and spinal cord, meningitis results in high mortality rates, with over 2.5 million new cases of bacterial meningitis and over 236,000 deaths worldwide in 2019 alone. Up to 30% of survivors have some type of neurological or neuro-behavioural sequelae. These include seizures, hearing and vision loss, cognitive impairment, neuromotor disability and memory or behaviour changes. Few studies have documented the long-term (greater than five years) consequences or have parsed out whether the age at time of meningitis contributes to poor outcome. Knowledge of the socioeconomic impact and demand for medical follow-up services among these patients and their caregivers is also lacking, especially in low- and middle-income countries (LMICs). Within resource-limited settings, the costs incurred by patients and their families can be very high. This review summarises the available evidence to better understand the impact and burden of the neurological sequelae and disabling consequences of bacterial meningitis, with particular focus on identifying existing gaps in LMICs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.