Evidence map›Paper›PMID 33922259›Full record

ReviewViruses2021

Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses.

Andrew B Janowski

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Article
  10. TwoViruses · 2025
    Article
  11. Article
  12. Article
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Structure of the divergent human astrovirus MLB capsid spike.Structure (London, England : 1993) · 2022
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Andrew B JanowskiDepartment of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.ORCID 0000-0003-4382-1194
Washington University in St. Louis · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
CHARACTERIZATION OF ASTROVIRUS VA1, A NOVEL NEUROTROPIC VIRUSK08AI132745 · NIAID · WASHINGTON UNIVERSITY · PI JANOWSKI, ANDREW BOK SENG · 2018 to 2022
$809k
NCATS NIH HHS UL1 TR002345NIAID NIH HHS K08 AI132745
6 · The paper itself

Abstract

Astroviruses are single stranded, positive-sense RNA viruses that have been historically associated with diseases of the gastrointestinal tract of vertebrates, including humans. However, there is now a multitude of evidence demonstrating the capacity of these viruses to cause extraintestinal diseases. The most striking causal relationship is neurological diseases in humans, cattle, pigs, and other mammals, caused by astrovirus infection. Astroviruses have also been associated with disseminated infections, localized disease of the liver or kidneys, and there is increasing evidence suggesting a potential tropism to the respiratory tract. This review will discuss the current understanding of the tissue tropisms for astroviruses and their emerging capacity to cause disease in multiple organ systems.

Indexed as

Disease SusceptibilityViral TropismAnimalsAstroviridaeAstroviridae InfectionsGastroenteritisGenetic VariationGenome, ViralHumansOrgan SpecificityRNA, ViralRNA, Viralastrovirusesencephalitisgastroenteritishepatitisrespiratory diseasetropism

Identifiers

PMID33922259
PMCPMC8145421
OpenAlexW3159016768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.