Evidence map›Paper›PMID 33922200›Full record

ArticleBiomedicines2021

Molecular Simplification of Natural Products: Synthesis, Antibacterial Activity, and Molecular Docking Studies of Berberine Open Models.

Gualtiero Milani, Maria Maddalena Cavalluzzi, Roberta Solidoro, Lara Salvagno, Laura Quintieri, Angela Di Somma, Antonio Rosato, Filomena Corbo, Carlo Franchini, Angela Duilio and 3 more

Abstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Berberine Extends Lifespan inAntioxidants (Basel, Switzerland) · 2025
    Article
  3. Berberine-styrene-RSC advances · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Review ofMolecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gualtiero MilaniDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.
Maria Maddalena CavalluzziDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.
Roberta SolidoroDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.
Lara SalvagnoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.
Laura QuintieriInstitute of Sciences of Food Production (CNR-ISPA) National Council of Research, Via G. Amendola, 122/O, 70126 Bari, Italy.ORCID 0000-0001-6261-9544
Angela Di SommaDepartment of Chemical Sciences, University of Naples "Federico II" Via Cinthia 4, 80126 Napoli, Italy.ORCID 0000-0003-4916-7875
Antonio RosatoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.ORCID 0000-0001-5462-4650
Filomena CorboDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.ORCID 0000-0002-6951-1103
Carlo FranchiniDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.
Angela DuilioDepartment of Chemical Sciences, University of Naples "Federico II" Via Cinthia 4, 80126 Napoli, Italy.
Leonardo CaputoInstitute of Sciences of Food Production (CNR-ISPA) National Council of Research, Via G. Amendola, 122/O, 70126 Bari, Italy.ORCID 0000-0002-6370-8562
Solomon HabtemariamPharmacognosy Research Laboratories & Herbal Analysis Services, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK.ORCID 0000-0001-6743-2244
Giovanni LentiniDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona n. 4, 70126 Bari, Italy.ORCID 0000-0001-7079-5994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Berberine, the main bioactive component of many medicinal plants belonging to various genera such as

Indexed as

antibacterial activityberberine‘fragment’FtsZligand efficiencymolecular simplification

Identifiers

PMID33922200
PMCPMC8146520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.