Evidence map›Paper›PMID 33922189›Full record

ArticleBiomedicines2021

Eps15 Homology Domain-Containing Protein 3 Hypermethylation as a Prognostic and Predictive Marker for Colorectal Cancer.

Yu-Han Wang, Shih-Ching Chang, Muhamad Ansar, Chin-Sheng Hung, Ruo-Kai Lin

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Yu-Han WangSchool of Medicine, Tzu Chi University, Hualien City 97071, Taiwan.
Shih-Ching ChangDivision of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan.ORCID 0000-0003-4947-2546
Muhamad AnsarPh.D. Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Chin-Sheng HungDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-9515-2036
Ruo-Kai LinPh.D. Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-5153-0824
Taipei Medical University · TWTaipei Medical University Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWTaipei Veterans General Hospital · TWTzu Chi University · TW

Funding

Ministry of Education (Republic of China) 108-5804-001-400Ministry of Science and Technology (Republic of China) MOST104-2320-B-038-051-MY3Ministry of Science and Technology (Republic of China) MOST108-2320-B-038-020
6 · The paper itself

Abstract

Colorectal cancer (CRC) arises from chromosomal instability, resulting from aberrant hypermethylation in tumor suppressor genes. This study identified hypermethylated genes in CRC and investigated how they affect clinical outcomes. Methylation levels of specific genes were analyzed from The Cancer Genome Atlas dataset and 20 breast cancer, 16 esophageal cancer, 33 lung cancer, 15 uterine cancer, 504 CRC, and 9 colon polyp tissues and 102 CRC plasma samples from a Taiwanese cohort. In the Asian cohort,

Indexed as

circulating cell-free DNA (ccfDNA)colorectal cancer (CRC)DNA methylationearly detectionEHD3prognostic marker

Identifiers

PMID33922189
PMCPMC8145505
OpenAlexW3154243722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.