Evidence map›Paper›PMID 33922065›Full record

ArticleMarine drugs2021

The Prospective Use of Brazilian Marine Macroalgae in Schistosomiasis Control.

Erika M Stein, Sara G Tajú, Patrícia A Miyasato, Rafaela P de Freitas, Lenita de F Tallarico, Guilherme S Dos Santos, Giovana L F Luiz, Henrique K Rofatto, Fábio N V da Silva, Pio Colepicolo and 3 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Erika M SteinLaboratory of Biochemistry and Molecular Biology of Marine Algae-Chemistry Institute, São Paulo University, São Paulo 05508-090, SP, Brazil.ORCID 0000-0002-3309-1944
Sara G TajúLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Patrícia A MiyasatoLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Rafaela P de FreitasLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Lenita de F TallaricoLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Guilherme S Dos SantosLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Giovana L F LuizLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Henrique K RofattoLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Fábio N V da SilvaLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Pio ColepicoloLaboratory of Biochemistry and Molecular Biology of Marine Algae-Chemistry Institute, São Paulo University, São Paulo 05508-090, SP, Brazil.
Arthur L MacedoLaboratory of Natural Products and Mass Spectrometry-LaPNEM, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.ORCID 0000-0002-0398-3167
Carlos A CarolloLaboratory of Natural Products and Mass Spectrometry-LaPNEM, Faculty of Pharmaceutical Sciences, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.ORCID 0000-0003-1231-9441
Eliana NakanoLaboratory of Parasitology, Butantan Institute, São Paulo 05503-900, SP, Brazil.ORCID 0000-0002-7839-9600
Instituto Butantan · BRUniversidade de São Paulo · BRUniversidade Federal de Mato Grosso do Sul · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/06931-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/16223-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/07346-0
6 · The paper itself

Abstract

Schistosomiasis is a parasitic disease that affects more than 250 million people. The treatment is limited to praziquantel and the control of the intermediate host with the highly toxic molluscicidal niclosamide. Marine algae are a poorly explored and promising alternative that can provide lead compounds, and the use of multivariate analysis could contribute to quicker discovery. As part of our search for new natural compounds with which to control schistosomiasis, we screened 45 crude extracts obtained from 37 Brazilian seaweed species for their molluscicidal activity against

Indexed as

BioprospectingDrug DiscoveryAnimalsBiomphalariaBrazilMetabolomeMetabolomicsMolluscacidesSchistosoma mansoniSchistosomiasis mansoniSchistosomicidesSeaweedMolluscacidesSchistosomicidesDictyotaditerpenesGC–MSLaurenciaLaurenciellametabolomic analysisPattern Hunter testPearson correlation testsesquiterpenes

Identifiers

PMID33922065
PMCPMC8143572
OpenAlexW3155136094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.