ReviewInternational journal of molecular sciences2021
Seminal Plasma: Relevant for Fertility?
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Seminal Extracellular Vesicles and Their Involvement in Male (In)Fertility: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Sperm Recovery and Evaluation in Domestic Species: Challenges and Current Practices.Reproduction in domestic animals = Zuchthygiene · 2026Review
- Seminal Extracellular Vesicles as Molecular Modulators of Male Reproductive Function.Reproduction in domestic animals = Zuchthygiene · 2026Review
- Small and Large Seminal Extracellular Vesicles Differentially Modulate Capacitation-Related Parameters in Frozen-Thawed Porcine Epididymal Spermatozoa.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Analysis of the Osmolarity of the Liquid Fraction of Squirrel Monkey's Semen (Saimiri collinsi Osgood, 1916) in Fattening and Non-Fattening Conditions.Journal of medical primatology · 2026Article
- Integration of Proteomics and Phenomics to Reveal Molecular Differences in High and Low Semen Quality in Donkeys.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Interplay Between Sperm Function and Seminal Plasma Biochemical Profile in a Group of Normozoospermic Subjects.Biomolecules · 2026Article
- Stratified profiling of azoospermia: Differentiating histological subtypes with seminal plasma metabolic signatures.Journal of biomedical research · 2026Article
- Osteoprotegerin is strongly associated with calcium and magnesium in seminal fluid but not affected by denosumab.Journal of endocrinological investigation · 2026Article
- The maternal immune response to semen: implications for reproductive success in livestock.Reproduction & fertility · 2026Review
- Article
- LCAT acts as a molecular switch and regulates rooster sperm motility in vitro.Molecular & cellular proteomics : MCP · 2026Article
- Winter-summer contrasts in metabolic, hormonal, and reproductive function of local buck goats in Mediterranean semi-extensive systems.Tropical animal health and production · 2026Article
- Characterization of Seminal Plasma Extracellular Vesicle MicroRNAs and Their Association with Boar Semen Quality During the Summer Season.International journal of molecular sciences · 2026Article
- Predominance of Biliverdin over Bilirubin in Human Seminal Plasma.Biomolecules · 2026Article
- Spatial localization of avian and human influenza A virus receptors in male and female bovine reproductive tissues.Scientific reports · 2026Article
- Seasonal Changes in the Seminal Plasma Proteome of the Crab-Eating Fox (Journal of proteome research · 2026Article
- Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers.Andrology · 2026Article
- Seminal Plasma and Extracellular Vesicles as Molecular Gatekeepers: Oxidative Stress, Endocrine Crosstalk, and Biomarker Discovery in Male Infertility.Current issues in molecular biology · 2026Review
- Male Stress Is Associated with Ovarian and Endometrial Responses in ICSI Cycles: Is Seminal Plasma the Linchpin?International journal of molecular sciences · 2026Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seminal plasma (SP), the non-cellular component of semen, is a heterogeneous composite fluid built by secretions of the testis, the epididymis and the accessory sexual glands. Its composition, despite species-specific anatomical peculiarities, consistently contains inorganic ions, specific hormones, proteins and peptides, including cytokines and enzymes, cholesterol, DNA and RNA-the latter often protected within epididymis- or prostate-derived extracellular vesicles. It is beyond question that the SP participates in diverse aspects of sperm function pre-fertilization events. The SP also interacts with the various compartments of the tubular genital tract, triggering changes in gene function that prepares for an eventual successful pregnancy; thus, it ultimately modulates fertility. Despite these concepts, it is imperative to remember that SP-free spermatozoa (epididymal or washed ejaculated) are still fertile, so this review shall focus on the differences between the in vivo roles of the SP following semen deposition in the female and those regarding additions of SP on spermatozoa handled for artificial reproduction, including cryopreservation, from artificial insemination to in vitro fertilization. This review attempts, including our own results on model animal species, to critically summarize the current knowledge of the reproductive roles played by SP components, particularly in our own species, which is increasingly affected by infertility. The ultimate goal is to reconcile the delicate balance between the SP molecular concentration and their concerted effects after temporal exposure in vivo. We aim to appraise the functions of the SP components, their relevance as diagnostic biomarkers and their value as eventual additives to refine reproductive strategies, including biotechnologies, in livestock models and humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.