Evidence map›Paper›PMID 33921982›Full record

ArticleMolecules (Basel, Switzerland)2021

Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies.

Guillermo Moya-Alvarado, Osvaldo Yañez, Nicole Morales, Angélica González-González, Carlos Areche, Marco Tulio Núñez, Angélica Fierro, Olimpo García-Beltrán

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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  14. Coumarin and Its Derivatives-Editorial.Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Guillermo Moya-AlvaradoBiology Department, Johns Hopkins University, Baltimore, MD 21218, USA.
Osvaldo YañezCenter of New Drugs for Hypertension (CENDHY), Santiago 8330015, Chile.ORCID 0000-0001-8993-9353
Nicole MoralesDepartment of Physiology, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile.
Angélica González-GonzálezLaboratorio de Interacciones Insecto-Planta, Instituto de Ciencias Biológicas, Universidad de Talca, Casilla 747, Talca 3460000, Chile.
Carlos ArecheDepartment of Chemistry, Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Nuñoa, Santiago 7800024, Chile.ORCID 0000-0001-5246-1368
Marco Tulio NúñezBiology Department, Faculty of Sciences, Universidad de Chile, Santiago 7800024, Chile.ORCID 0000-0002-1967-8570
Angélica FierroDepartment of Organic Chemistry, Faculty of Chemistry, Pontificia Universidad Católica de Chile, Casilla 306, Santiago 6094411, Chile.ORCID 0000-0002-6507-4188
Olimpo García-BeltránCentro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O'Higgins, General Gana 1702, Santiago 8370854, Chile.ORCID 0000-0003-3312-1776
Pontificia Universidad Católica de Chile · CLUniversity of Chile · CLJohns Hopkins University · USUniversidad Andrés Bello · CLUniversidad Bernardo O'Higgins · CLUniversity of Talca · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fourteen coumarin-derived compounds modified at the C3 carbon of coumarin with an α,β-unsaturated ketone were synthesized. These compounds may be designated as chalcocoumarins (3-cinnamoyl-2

Indexed as

AnimalsBinding SitesChalconesCoumarinsDose-Response Relationship, DrugHumansLigandsMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructureMonoamine OxidaseMonoamine Oxidase InhibitorsProtein BindingRatsStructure-Activity RelationshipChalconescoumarinCoumarinsLigandsMonoamine OxidaseMonoamine Oxidase Inhibitorschalcocoumarinin silico studiesMAO-Bmolecular dynamicsneurodegenerative diseases

Identifiers

PMID33921982
PMCPMC8122463
OpenAlexW3155309497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.