The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same.

Rachel McNamar, Katrina Rothblum, Lawrence I Rothblum

Open access · goldAbstract readReview

In one paragraph

Review in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans.Life science alliance · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rachel McNamarDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0001-5422-5617

Katrina RothblumDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Lawrence I RothblumDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

University of Oklahoma Health Sciences Center · US

Funding

RNA Polymerase I Associated Factors: Novel Targets in Cancer TherapyF31CA250352 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MCNAMAR, RACHEL · 2021 to 2022

$68k

NCI NIH HHS F31 CA250352NIH HHS F31CA250352NIH HHS GM069841NIH HHS HL077814

6 · The paper itself

Abstract

Ribosomal RNA synthesis is the rate-limiting step in ribosome biogenesis. In eukaryotes, RNA polymerase I (Pol I) is responsible for transcribing the ribosomal DNA genes that reside in the nucleolus. Aberrations in Pol I activity have been linked to the development of multiple cancers and other genetic diseases. Therefore, it is key that we understand the mechanisms of Pol I transcription. Recent studies have demonstrated that there are many differences between Pol I transcription in yeast and mammals. Our goal is to highlight the similarities and differences between the polymerase-associated factors (PAFs) in yeast and mammalian cells. We focus on the PAF heterodimer A49/34 in yeast and PAF53/49 in mammals. Recent studies have demonstrated that while the structures between the yeast and mammalian orthologs are very similar, they may function differently during Pol I transcription, and their patterns of regulation are different.

Indexed as

AnimalsCell NucleolusDNA, RibosomalMammalsProtein ConformationProtein MultimerizationRibosomesRNA Polymerase IRNA, RibosomalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsTranscription, GeneticDNA, RibosomalRNA Polymerase IRNA, RibosomalSaccharomyces cerevisiae ProteinsTranscription Factorsribosome biogenesisRNA polymerase IrRNA transcription

Identifiers

PMID33921963

DOI10.3390/genes12050620

PMCPMC8143541

OpenAlexW3155072406

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.