Evidence map›Paper›PMID 33921883›Full record

ArticleBiomolecules2021

The Effect of a Unique Region of Parvovirus B19 Capsid Protein VP1 on Endothelial Cells.

Ieva Rinkūnaitė, Egidijus Šimoliūnas, Daiva Bironaitė, Rasa Rutkienė, Virginija Bukelskienė, Rolandas Meškys, Julius Bogomolovas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ieva RinkūnaitėDepartment of Biological Models, Life Sciences Center, Institute of Biochemistry, Vilnius University, LT-10257 Vilnius, Lithuania.ORCID 0000-0001-9956-4022
Egidijus ŠimoliūnasDepartment of Biological Models, Life Sciences Center, Institute of Biochemistry, Vilnius University, LT-10257 Vilnius, Lithuania.ORCID 0000-0001-5440-3591
Daiva BironaitėDepartment of Regenerative Medicine, Center for Innovative Medicine, State Research Institute, LT-08406 Vilnius, Lithuania.
Rasa RutkienėDepartment of Molecular Microbiology and Biotechnology, Life Sciences Center, Institute of Biochemistry, Vilnius University, LT-10257 Vilnius, Lithuania.
Virginija BukelskienėDepartment of Biological Models, Life Sciences Center, Institute of Biochemistry, Vilnius University, LT-10257 Vilnius, Lithuania.
Rolandas MeškysDepartment of Molecular Microbiology and Biotechnology, Life Sciences Center, Institute of Biochemistry, Vilnius University, LT-10257 Vilnius, Lithuania.ORCID 0000-0003-3125-9827
Julius BogomolovasDepartment of Medicine, School of Medicine, UCSD, La Jolla, CA 92093, USA.ORCID 0000-0001-8344-1909
Vilnius University · LTState Research Institute Centre for Innovative Medicine · LTUniversity of California San Diego · US

Funding

H2020 Marie Skłodowska-Curie Actions 656636Research Council of Lithuania MIP-14205Vilnius University Science Promotion Fund MSF-JM-11
6 · The paper itself

Abstract

Parvovirus B19 (B19V) is a widespread human pathogen possessing a high tropism for erythroid precursor cells. However, the persistence or active replication of B19V in endothelial cells (EC) has been detected in diverse human pathologies. The VP1 unique region (VP1u) of the viral capsid has been reported to act as a major determinant of viral tropism for erythroid precursor cells. Nevertheless, the interaction of VP1u with EC has not been studied. We demonstrate that recombinant VP1u is efficiently internalized by rats' pulmonary trunk blood vessel-derived EC in vitro compared to the human umbilical vein EC line. The exposure to VP1u was not acutely cytotoxic to either human- or rat-derived ECs, but led to the upregulation of cellular stress signaling-related pathways. Our data suggest that high levels of circulating B19V during acute infection can cause endothelial damage, even without active replication or direct internalization into the cells.

Indexed as

AnimalsCells, CulturedCell SurvivalHumansHuman Umbilical Vein Endothelial CellsMAP Kinase Signaling SystemParvovirus B19, HumanPulmonary ArteryRatsRats, WistarRecombinant ProteinsViral Fusion ProteinsRecombinant ProteinsViral Fusion Proteinsendothelial cellsendothelial stressparvovirus B19VP1u

Identifiers

PMID33921883
PMCPMC8073096
OpenAlexW3156078236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.