Evidence map›Paper›PMID 33921802›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Natural Chain-Breaking Antioxidants and Their Synthetic Analogs as Modulators of Oxidative Stress.

Vessela D Kancheva, Maria Antonietta Dettori, Davide Fabbri, Petko Alov, Silvia E Angelova, Adriana K Slavova-Kazakova, Paola Carta, Valerii A Menshov, Olga I Yablonskaya, Aleksei V Trofimov and 2 more

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vessela D KanchevaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str., bl.9, 1113 Sofia, Bulgaria.
Maria Antonietta DettoriCNR, Istituto di Chimica Biomolecolare, Traversa La Crucca 3, 07100 Sassari, Italy.ORCID 0000-0002-8776-9271
Davide FabbriCNR, Istituto di Chimica Biomolecolare, Traversa La Crucca 3, 07100 Sassari, Italy.
Petko AlovInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str., bl.21, 1113 Sofia, Bulgaria.ORCID 0000-0003-1320-2173
Silvia E AngelovaInstitute of Optical Materials and Technologies "Acad. J. Malinowski", Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str., bl.109, 1113 Sofia, Bulgaria.ORCID 0000-0003-4717-8028
Adriana K Slavova-KazakovaInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str., bl.9, 1113 Sofia, Bulgaria.ORCID 0000-0003-1270-792X
Paola CartaCNR, Istituto di Chimica Biomolecolare, Traversa La Crucca 3, 07100 Sassari, Italy.ORCID 0000-0001-8749-6093
Valerii A MenshovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, "Kosigina"4 Str., 119334 Moscow, Russia.ORCID 0000-0002-9183-8292
Olga I YablonskayaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, "Kosigina"4 Str., 119334 Moscow, Russia.
Aleksei V TrofimovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, "Kosigina"4 Str., 119334 Moscow, Russia.ORCID 0000-0003-2472-601X
Ivanka TsakovskaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, "Acad. G. Bonchev" Str., bl.21, 1113 Sofia, Bulgaria.ORCID 0000-0003-1389-1685
Luciano SasoDepartment of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University, P.le Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0003-4530-8706

Funding

Bulgarian National Science Fund КP-06-Russia-28
6 · The paper itself

Abstract

Oxidative stress is associated with the increased production of reactive oxygen species or with a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic defense. The penetration of oxygen and free radicals in the hydrophobic interior of biological membranes initiates radical disintegration of the hydrocarbon "tails" of the lipids. This process is known as "lipid peroxidation", and the accumulation of the oxidation products as peroxides and the aldehydes and acids derived from them are often used as a measure of oxidative stress levels. In total, 40 phenolic antioxidants were selected for a comparative study and analysis of their chain-breaking antioxidant activity, and thus as modulators of oxidative stress. This included natural and natural-like

Indexed as

bio-antioxidantchain breaking antioxidant activityoxidative stressstructure–activity relationshipsynthesis

Identifiers

PMID33921802
PMCPMC8074124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.