Evidence map›Paper›PMID 33921583›Full record

ReviewPathogens (Basel, Switzerland)2021

Gene Regulation of Biofilm-Associated Functional Amyloids.

Khushal Khambhati, Jaykumar Patel, Vijaylaxmi Saxena, Parvathy A, Neha Jain

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A molecular toolkit for heterologous protein secretion acrossbioRxiv : the preprint server for biology · 2023
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Anti-Biofilm Molecules Targeting Functional Amyloids.Antibiotics (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Khushal KhambhatiDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, India.
Jaykumar PatelDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, India.
Vijaylaxmi SaxenaDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, India.
Parvathy ADepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, India.
Neha JainDepartment of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur NH 65, Nagaur Road, Karwar, Rajasthan 342037, India.
Indian Institute of Technology Jodhpur · IN

Funding

Indian Institute of technology Jodhpur I/SEED/NJ/20190019Science and Engineering Research Board ECR/2018/002490
6 · The paper itself

Abstract

Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of biofilm biogenesis is an intriguingly complex phenomenon governed by the tight regulation of expression of various biofilm-matrix components. One of the major constituents of the biofilm matrix is proteinaceous polymers called amyloids. Since the discovery, the significance of biofilm-associated amyloids in adhesion, aggregation, protection, and infection development has been much appreciated. The amyloid expression and assembly is regulated spatio-temporarily within the bacterial cells to perform a diverse function. This review provides a comprehensive account of the genetic regulation associated with the expression of amyloids in bacteria. The stringent control ensures optimal utilization of amyloid scaffold during biofilm biogenesis. We conclude the review by summarizing environmental factors influencing the expression and regulation of amyloids.

Indexed as

biofilmsCsgAextracellular matrixfunctional amyloidsgene regulationPSMTasA

Identifiers

PMID33921583
PMCPMC8072697
OpenAlexW3154280768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.