Evidence map›Paper›PMID 33921566›Full record

ArticleCancers2021

Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries.

Swathi Kaliki, Xunda Ji, Yihua Zou, Riffat Rashid, Sadia Sultana, Sadik Taju Sherief, Nathalie Cassoux, Rosdali Y Diaz Coronado, Juan Luis Garcia Leon, Arturo Manuel Zapata López and 24 more

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  11. The first retinoblastoma local experience in Kuwait: A retrospective case series.American journal of ophthalmology case reports · 2024
    Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Swathi KalikiThe Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad 500034, India.ORCID 0000-0002-0800-9961
Xunda JiDepartment of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yihua ZouDepartment of Ophthalmology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Riffat RashidDepartment of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka 1215, Bangladesh.
Sadia SultanaDepartment of Oculoplasty and Ocular Oncology, Ispahani Islamia Eye Institute and Hospital, Dhaka 1215, Bangladesh.
Sadik Taju SheriefDepartment of Ophthalmology, School of Medicine, Addis Ababa University, Addis Ababa 3614, Ethiopia.ORCID 0000-0003-4614-4563
Nathalie CassouxInstitut Curie, Université de Paris Medicine Paris V Descartes, 75248 Paris, France.
Rosdali Y Diaz CoronadoInstituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.ORCID 0000-0002-1849-2256
Juan Luis Garcia LeonAnglo American Clinic, Lima 15073, Peru.
Arturo Manuel Zapata LópezInstituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.ORCID 0000-0002-3423-1988
Vladimir G PolyakovHead and Neck Tumors Department, SRI of Pediatric Oncology and Hematology, N.N. Blokhin National Medical Research Center, Oncology of Russian Federation, 115478 Moscow, Russia.
Tatiana L UshakovaHead and Neck Tumors Department, SRI of Pediatric Oncology and Hematology, N.N. Blokhin National Medical Research Center, Oncology of Russian Federation, 115478 Moscow, Russia.
Soma Rani RoyChittagong Eye Infirmary & Training Complex, Chittagong 4202, Bangladesh.
Alia AhmadThe Children' Hospital & the Institute of Child Health, Lahore 54000, Pakistan.ORCID 0000-0001-6520-845X
Lamis Al HarbyThe Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.ORCID 0000-0001-9367-8395
M Ashwin ReddyThe Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.ORCID 0000-0001-6624-1518
Mandeep S SagooThe Royal London Hospital, Barts Health NHS Trust, London E1 1BB, UK.ORCID 0000-0003-1530-3824
Jesse L BerryChildren's Hospital Los Angeles & USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0002-8907-9100
Jonathan KimChildren's Hospital Los Angeles & USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.
Ashley PolskiChildren's Hospital Los Angeles & USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.ORCID 0000-0001-6301-6892
Nicholas J AstburyInternational Centre for Eye Health London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0002-8123-4823
Covadonga BascaranInternational Centre for Eye Health London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Sharon BlumGoldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv 52621, Israel.
Richard BowmanInternational Centre for Eye Health London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Matthew J BurtonUCL Institute of Ophthalmology, London EC1V 2PD, UK.
Allen FosterInternational Centre for Eye Health London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Nir GomelDivision of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 39040, Israel.
Naama Keren-FroimGoldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv 52621, Israel.
Shiran MadgarGoldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv 52621, Israel.
Andrew W StaceyDepartment of Ophthalmology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-4441-6302
David M SteinbergDepartment of Statistics and Operations Research, School of Mathematical Sciences, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.ORCID 0000-0001-9112-1809
Ashik MohamedOphthalmic Biophysics, L V Prasad Eye Institute, Hyderabad 500034, India.ORCID 0000-0001-5520-4930
Marcia ZondervanInternational Centre for Eye Health London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Ido Didi FabianInternational Centre for Eye Health London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.ORCID 0000-0002-0846-5131

Funding

Wellcome Trust 207472/Z/17/Z
6 · The paper itself

Abstract

backgroundThe relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes.

methodsWe performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019.

resultsThe following factors were significantly different among different countries based on national-income level: age at diagnosis of RB (

conclusionsThere is a significant difference in the lag time between onset of signs and symptoms and referral to an RB treatment centre among countries based on national income resulting in significant differences in the presenting features and clinical outcomes.

Indexed as

eyelag timenational income levelretinoblastomatumour

Identifiers

PMID33921566
PMCPMC8073369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.