ReviewInternational journal of molecular sciences2021
Treatment of Stress Urinary Incontinence with Muscle Stem Cells and Stem Cell Components: Chances, Challenges and Future Prospects.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring the role of laser therapy for stress urinary incontinence: a literature review.Lasers in medical science · 2025Pooled it
- Stem Cells in Clinical Trials for Pelvic Floor Disorders: a Systematic Literature Review.Reproductive sciences (Thousand Oaks, Calif.) · 2022Pooled it
- Stem cell therapy for female stress urinary incontinence: Results, limitations and lessons learned from a pilot clinical study.PloS one · 2026Trial
- Implantation of Autologous Skeletal Muscle-Derived Cells Combined with Electrical Stimulation in Patients with Stress Urinary Incontinence.International urogynecology journal · 2025Trial
- Human Muscle-Derived Cells Injected into Acute and Chronic Muscle Injuries Engraft and Support Regenerative Markers.Bioengineering (Basel, Switzerland) · 2026Article
- Regenerative Medicine Approaches to Stress Urinary Incontinence.Biomimetics (Basel, Switzerland) · 2026Review
- Physiological medium and 3-hydroxybutyrate modulate autophagy-linked organelle remodeling in human external urethral sphincter myoblasts.Scientific reports · 2026Article
- Positive relationship between an aggregate index of systemic inflammation and stress urinary incontinence: a nationwide cross-sectional analysis.Translational andrology and urology · 2026Article
- Improved Sphincter Muscle Regeneration by Myoblasts fromMedical sciences (Basel, Switzerland) · 2026Article
- A Novel Technology for Needle-Free Injections of Liquids, Particles and Viable Cells into the Submucosa of the Urethra by a Pressure-Controlled Waterjet Technology.Biomedicines · 2025Article
- Guarding Reflex Inhibition Training Reduces Postoperative Urinary Retention After Urethral Bulking for Stress Urinary Incontinence: A Retrospective Single-Center Study.Journal of clinical medicine · 2025Article
- Metabolic dynamics of human external urethral sphincter myoblast differentiation and the effects of tricarboxylic acid cycle inhibition.Scientific reports · 2025Article
- Dynamic URP: Revisiting Urethral Retro-Resistance Pressure for Contemporary Sphincter-Targeted Therapy.Diagnostics (Basel, Switzerland) · 2025Review
- The Outcome of Cell Therapy Treating Urinary Incontinence Correlates with Precise Cell Localization in the Sphincter Complex.Biomedicines · 2025Article
- Relationship Between the PERFECT Scheme, Vaginal Manometry, and Transperineal Ultrasound in Women With and Without Stress Urinary Incontinence: A Cross-Sectional Study.International urogynecology journal · 2025Article
- Cytokine modulation in pelvic organ prolapse and urinary incontinence: from molecular insights to therapeutic targets.Molecular medicine (Cambridge, Mass.) · 2024Review
- Cellular regenerative therapy in stress urinary incontinence: new frontiers?-a narrative review.Translational andrology and urology · 2024Review
- Cell Therapy in the Treatment of Female Stress Urinary Incontinence: Current Status and Future Proposals.Life (Basel, Switzerland) · 2024Review
- Association of plasma high-density lipoprotein cholesterol level with risk of stress urinary incontinence in women: a retrospective study.Lipids in health and disease · 2024Article
- Production of Proliferation- and Differentiation-Competent Porcine Myoblasts for Preclinical Studies in a Porcine Large Animal Model of Muscular Insufficiency.Life (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary incontinence (UI) is a major problem in health care and more than 400 million people worldwide suffer from involuntary loss of urine. With an increase in the aging population, UI is likely to become even more prominent over the next decades and the economic burden is substantial. Among the different subtypes of UI, stress urinary incontinence (SUI) is the most prevalent and focus of this review. The main underlying causes for SUI are pregnancy and childbirth, accidents with direct trauma to the pelvis or medical treatments that affect the pelvic floor, such as surgery or irradiation. Conservative approaches for the treatment of SUI are pelvic physiotherapy, behavioral and lifestyle changes, and the use of pessaries. Current surgical treatment options include slings, colposuspensions, bulking agents and artificial urinary sphincters. These treatments have limitations with effectiveness and bear the risk of long-term side effects. Furthermore, surgical options do not treat the underlying pathophysiological causes of SUI. Thus, there is an urgent need for alternative treatments, which are effective, minimally invasive and have only a limited risk for adverse effects. Regenerative medicine is an emerging field, focusing on the repair, replacement or regeneration of human tissues and organs using precursor cells and their components. This article critically reviews recent advances in the therapeutic strategies for the management of SUI and outlines future possibilities and challenges.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.