Evidence map›Paper›PMID 33921479›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis, Biological Evaluation, and Molecular Modeling of Aza-Crown Ethers.

Stepan S Basok, Igor A Schepetkin, Andrei I Khlebnikov, Anatoliy F Lutsyuk, Tatiana I Kirichenko, Liliya N Kirpotina, Victor I Pavlovsky, Klim A Leonov, Darya A Vishenkova, Mark T Quinn

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Stepan S BasokA.V. Bogatsky Physico-Chemical Institute of National Academy of Science of Ukraine, 65080 Odessa, Ukraine.
Igor A SchepetkinDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Andrei I KhlebnikovKizhner Research Center, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.ORCID 0000-0002-3022-4510
Anatoliy F LutsyukA.V. Bogatsky Physico-Chemical Institute of National Academy of Science of Ukraine, 65080 Odessa, Ukraine.ORCID 0000-0002-8822-6551
Tatiana I KirichenkoA.V. Bogatsky Physico-Chemical Institute of National Academy of Science of Ukraine, 65080 Odessa, Ukraine.
Liliya N KirpotinaDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Victor I PavlovskyKizhner Research Center, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.
Klim A LeonovInnovative Pharmacology Research, LLC, Tomsk 634021, Russia.
Darya A VishenkovaKizhner Research Center, National Research Tomsk Polytechnic University, Tomsk 634050, Russia.
Mark T QuinnDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0001-8114-5073
Montana State University · USNational Research Tomsk State University · RU

Funding

NIH HHS GM103474NIH HHS GM115371U.S. Department of Agriculture 1009546
6 · The paper itself

Abstract

Synthetic and natural ionophores have been developed to catalyze ion transport and have been shown to exhibit a variety of biological effects. We synthesized 24 aza- and diaza-crown ethers containing adamantyl, adamantylalkyl, aminomethylbenzoyl, and ε-aminocaproyl substituents and analyzed their biological effects in vitro. Ten of the compounds (

Indexed as

Models, MolecularAza CompoundsCalciumChemotaxisCrown EthersDensity Functional TheoryHL-60 CellsHumansLigandsNeutrophilsReactive Oxygen SpeciesReceptors, Formyl PeptideRegression AnalysisStatic ElectricityThermodynamicsAza CompoundsCalciumCrown EthersLigandsReactive Oxygen SpeciesReceptors, Formyl Peptideaza-crown etherdensity-functional theory (DFT)ionophoreneutrophilquantitative structure-activity relationship (QSAR) modeling

Identifiers

PMID33921479
PMCPMC8069214
OpenAlexW3156424237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.