Evidence map›Paper›PMID 33921370›Full record

ArticleInternational journal of environmental research and public health2021

Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering.

Jukka Hintikka, Sanna Lensu, Elina Mäkinen, Sira Karvinen, Marjaana Honkanen, Jere Lindén, Tim Garrels, Satu Pekkala, Leo Lahti

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Biclustering data analysis: a comprehensive survey.Briefings in bioinformatics · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Biochemical Basis of Xylooligosaccharide Utilisation by Gut Bacteria.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jukka HintikkaFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.ORCID 0000-0002-0481-1957
Sanna LensuFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.ORCID 0000-0001-8197-7590
Elina MäkinenFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
Sira KarvinenFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
Marjaana HonkanenFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
Jere LindénVeterinary Pathology and Parasitology and Finnish Centre for Laboratory Animal Pathology/HiLIFE, University of Helsinki, FIN-00014 Helsinki, Finland.ORCID 0000-0001-9872-3626
Tim GarrelsDepartment of Computing, University of Turku, FI-20014 Turku, Finland.
Satu PekkalaFaculty of Sport and Health Sciences, University of Jyväskylä, FI-40014 Jyväskylä, Finland.
Leo LahtiDepartment of Computing, University of Turku, FI-20014 Turku, Finland.ORCID 0000-0001-5537-637X
University of Jyväskylä · FIUniversity of Turku · FITurku University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (

Indexed as

Fatty LiverAdipose TissueAnimalsDiet, High-FatInflammationLiverMaleOligosaccharidesRatsRats, WistarOligosaccharidesbiclusteringgut microbiotahigh fat dietmetabolitesmicroRNAnon-alcoholic fatty liver diseaseratsxylo-oligosaccharides

Identifiers

PMID33921370
PMCPMC8068902
OpenAlexW3135750648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.