Evidence map›Paper›PMID 33921293›Full record

Observational studyNutrients2021

Non-Celiac Gluten/Wheat Sensitivity: Clinical Characteristics and Microbiota and Mycobiota Composition by Response to the Gluten Challenge Test.

Valentina Ponzo, Ilario Ferrocino, Ilaria Goitre, Marianna Pellegrini, Mauro Bruno, Marco Astegiano, Gianni Cadario, Eleonora Castellana, Fabio Bioletto, Maria Rita Corvaglia and 4 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Valentina PonzoDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.
Ilario FerrocinoDepartment of Agricultural, Forestry and Food Science, University of Torino, 10095 Torino, Italy.ORCID 0000-0002-1657-0054
Ilaria GoitreDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.
Marianna PellegriniDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.
Mauro BrunoGastroenterology and Digestive Endoscopy Unit, "Città della Salute e della Scienza" Hospital, 10126 Torino, Italy.
Marco AstegianoGastroenterology and Digestive Endoscopy Unit, "Città della Salute e della Scienza" Hospital, 10126 Torino, Italy.
Gianni CadarioAllergology and Clinical Immunology Unit, "Città della Salute e della Scienza" Hospital, 10126 Torino, Italy.
Eleonora CastellanaHospital Pharmacy, "Città della Salute e della Scienza" Hospital, 10126 Torino, Italy.
Fabio BiolettoDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.
Maria Rita CorvagliaDepartment of Agricultural, Forestry and Food Science, University of Torino, 10095 Torino, Italy.
Patrizia MalfaProge Farm, 28100 Novara, Italy.
Luca CocolinDepartment of Agricultural, Forestry and Food Science, University of Torino, 10095 Torino, Italy.ORCID 0000-0003-4799-7074
Ezio GhigoDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.
Simona BoDepartment of Medical Sciences, University of Torino, 10126 Torino, Italy.ORCID 0000-0001-6862-8628
University of Turin · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITPROGE FARM (Italy) · IT

Funding

Fondazione cassa di risparmio di Torino PROBIOSENS project
6 · The paper itself

Abstract

The aims of this observational "proof-of-concept" study were to analyze the clinical/psychological characteristics and gut microbiota/mycobiota composition of individuals with suspected non-celiac gluten/wheat sensitivity (NCGS/WS) according to responses to the double-blind-placebo-controlled (DBPC) crossover gluten challenge test. Fifty individuals with suspected NCGS/WS were subjected to the DBPC challenge test; anthropometric measurements, psychometric questionnaires, and fecal samples were collected. Twenty-seven (54%) participants were gluten responsive (NCGS), and 23 were placebo responsive, with an order effect. NCGS individuals displayed a significantly lower risk of eating disorders and a higher mental health score when compared to placebo-responsive participants, confirmed by multiple logistic regression analyses (OR = 0.87; 95% CI 0.76-0.98,

Indexed as

AdultCross-Over StudiesDouble-Blind MethodFecesFeeding and Eating DisordersFemaleGastrointestinal MicrobiomeGlutensHumansImmunologic TestsMaleMental HealthMiddle AgedMycobiomePlacebosProof of Concept StudyGlutensPlacebosgluten sensitivitygut microbiotagut mycobiotamental status

Identifiers

PMID33921293
PMCPMC8070191
OpenAlexW3156915957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.