ArticleJournal of clinical medicine2021
Association of Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional Study of Community-Dwelling Japanese Older Adults.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Association between oral health status and frailty in older adults: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Association between oral hypofunction and general health: a systematic review.BMC oral health · 2023Pooled it
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Pooled it
- Associations between self-reported masticatory dysfunction and frailty: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Bibliometric Analysis of Research Trends and Knowledge Structure in Oral Frailty.Gerodontology · 2026Review
- Bilateral Gum Chewing as Proprioceptive Sensorimotor Re-Education for Patients with Masticatory Muscle Weakness Presenting with Orofacial Pain and Perceived Occlusal Change: A Technical Note with a Retrospective Case Series.Bioengineering (Basel, Switzerland) · 2026Article
- Article
- Relationships Between Salivary Biomarkers and Oral Function in Elderly People Using a Saliva Testing Device.Dentistry journal · 2026Article
- Relationships of Oral Function Tests With Sarcopenia and Frailty in Dental Outpatients.Journal of oral rehabilitation · 2026Article
- Role of Posterior Occlusal Support in the Development of Frailty Among Japanese Adults: A Longitudinal Cohort Study.Geriatrics & gerontology international · 2026Article
- Mediating effect of social frailty on oral frailty and cognitive function in older adults: a cross-sectional study in a rural Chinese community.Frontiers in aging neuroscience · 2026Article
- Association of physical frailty, functional dependence, dysphagia, and depression with mild cognitive impairment in hospitalized older adults.Frontiers in medicine · 2026Article
- Cross-cultural adaptation and psychometric validation of the simplified Oral Frailty Index (OFI-8) among Indonesian older adults.Frontiers in oral health · 2026Article
- Factors associated with oral frailty among community-dwelling older adults in Chengdu, China: a cross-sectional study.BMC geriatrics · 2025Article
- Predicting cognitive decline using tongue pressure: a novel, non-invasive screening strategy for dementia in geriatric dentistry.Acta neurologica Belgica · 2025Article
- Reduced Tongue Pressure as a Risk Factor for Sarcopenia in Community-Dwelling Older Adults: A Cross-Sectional Analysis.Journal of oral rehabilitation · 2025Article
- Association between toothbrushing habits and hypertension in the general population.Scientific reports · 2025Article
- Oral frailty and nutritional appetite in older adults: a cross-sectional, moderated mediation model of oral self-efficacy and personal mastery.BMC oral health · 2025Article
- Association between malnutrition and low tongue pressure in community-dwelling older people: a population-based cohort study.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
21 authors at 2 institutions in 1 country.
Funding
Abstract
Oral hypofunction is a new concept that addresses the oral function of older adults. Few studies have investigated the relationship between oral hypofunction and general health conditions such as frailty, sarcopenia, and mild cognitive impairment. This paper explores these relationships in a large-scale, cross-sectional cohort study. The relationships of oral hypofunction with frailty, sarcopenia, and mild cognitive impairment were examined using data from 832 individuals who participated in the 2018 health survey of the residents of Tarumizu City, Kagoshima Prefecture, Japan. Individuals with frailty, sarcopenia, and mild cognitive impairment had significantly higher rates of oral hypofunction. Frailty was independently associated with deterioration of the swallowing function (odds ratio 2.56; 95% confidence interval, 1.26-5.20), and mild cognitive impairment was independently associated with reduced occlusal force (odds ratio 1.48; 95% confidence interval, 1.05-2.08) and decreased tongue pressure (odds ratio 1.77; 95% confidence interval, 1.28-2.43). There was no independent association found between sarcopenia and oral function. In conclusion, early intervention for related factors such as deterioration of the swallowing function in frailty, reduced occlusal force, and decreased tongue pressure in mild cognitive impairment could lead to the prevention of general hypofunction in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.