Evidence map›Paper›PMID 33921252›Full record

ArticleMolecules (Basel, Switzerland)2021

Synthesis and Evaluation of Novel 2,2-Dimethylthiochromanones as Anti-Leishmanial Agents.

Seán Coll, Mohammad Alhazmi, Patrícia de Aguiar Amaral, Sandra Bourgeade-Delmas, Anne-Cécile Le Lamer, James W Barlow

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Seán CollDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
Mohammad AlhazmiDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.
Patrícia de Aguiar AmaralLaboratory of Medicinal Plants (LaPlaM/PPGCA), Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitária 1105, Bairro Universitário, Criciúma 88806-000, SC, Brazil.
Sandra Bourgeade-DelmasUMR 152 IRD-UPS PHARMADEV, Faculté des Sciences Pharmaceutiques, Université Toulouse III-Paul Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse CEDEX 09, France.
Anne-Cécile Le LamerUMR 152 IRD-UPS PHARMADEV, Faculté des Sciences Pharmaceutiques, Université Toulouse III-Paul Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse CEDEX 09, France.
James W BarlowDepartment of Chemistry, RCSI University of Medicine and Health Sciences, 123 St. Stephen's Green, Dublin 2, Ireland.ORCID 0000-0002-1663-4580
Royal College of Surgeons in Ireland · IEUniversité Toulouse III - Paul Sabatier · FRCentro Universitário do Espírito Santo · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES-CSF-PVE-S (Programa Pesquisador Visitante Especial) Processo: 88881.064993/2014-01
6 · The paper itself

Abstract

Within this work, we describe the design and synthesis of a range of novel thiochromanones based on natural products reported to possess anti-leishmanial action, and their synthetic derivatives. All compounds were elaborated via the key intermediate 2,2,6-trimethoxythiochromanone, which was modified at the benzylic position to afford various ester, amine and amide analogues, substituted by chains of varying lipophilicity. Upon testing in

Indexed as

AnimalsAntiprotozoal AgentsBiological ProductsCell LineChromonesLeishmaniaMiceParasitic Sensitivity TestsAntiprotozoal AgentsBiological ProductsChromonesgibbilimbolLeishmaniathiochromanoneuniflorol

Identifiers

PMID33921252
PMCPMC8069510
OpenAlexW3153817117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.