Evidence map›Paper›PMID 33921179›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Fluorescently Labeled Cellulose Nanofibers for Environmental Health and Safety Studies.

Ilabahen Patel, Jeremiah Woodcock, Ryan Beams, Stephan J Stranick, Ryan Nieuwendaal, Jeffrey W Gilman, Marina R Mulenos, Christie M Sayes, Maryam Salari, Glen DeLoid and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Ilabahen PatelDepartment of Chemistry, American University, Washington, DC 20016, USA.
Jeremiah WoodcockMaterials Science and Engineering Division, Materials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Ryan BeamsMaterials Science and Engineering Division, Materials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.ORCID 0000-0003-2592-6064
Stephan J StranickMaterials Science and Engineering Division, Materials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Ryan NieuwendaalMaterials Science and Engineering Division, Materials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Jeffrey W GilmanMaterials Science and Engineering Division, Materials Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
Marina R MulenosDepartment of Environmental Science, Baylor University, Waco, TX 76798, USA.ORCID 0000-0002-9261-2797
Christie M SayesDepartment of Environmental Science, Baylor University, Waco, TX 76798, USA.ORCID 0000-0002-5529-4101
Maryam SalariDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Glen DeLoidDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Philip DemokritouDepartment of Environmental Health, Center for Nanotechnology and Nanotoxicology, T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.
Bryan HarperDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0003-1359-8446
Stacey HarperDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0001-7043-7097
Kimberly J OngVireo Advisors, LLC, Boston, MA 02130, USA.
Jo Anne ShatkinVireo Advisors, LLC, Boston, MA 02130, USA.ORCID 0000-0001-9015-8642
Douglas M FoxDepartment of Chemistry, American University, Washington, DC 20016, USA.
National Institute of Standards and Technology · USHarvard University · USAmerican University · USBaylor University · USHealthcentric Advisors · USOregon State University · US

Funding

P3Nano E16-39
6 · The paper itself

Abstract

An optimal methodology for locating and tracking cellulose nanofibers (CNFs) in vitro and in vivo is crucial to evaluate the environmental health and safety properties of these nanomaterials. Here, we report the use of a new boron-dipyrromethene (BODIPY) reactive fluorescent probe, meso-DichlorotriazineEthyl BODIPY (mDTEB), tailor-made for labeling CNFs used in simulated or in vivo ingestion exposure studies. Time-correlated single photon counting (TCSPC) fluorescence lifetime imaging microscopy (FLIM) was used to confirm covalent attachment and purity of mDTEB-labeled CNFs. The photoluminescence properties of mDTEB-labeled CNFs, characterized using fluorescence spectroscopy, include excellent stability over a wide pH range (pH2 to pH10) and high quantum yield, which provides detection at low (μM) concentrations. FLIM analysis also showed that lignin-like impurities present on the CNF reduce the fluorescence of the mDTEB-labeled CNF, via quenching. Therefore, the chemical composition and the methods of CNF production affect subsequent studies. An in vitro triculture, small intestinal, epithelial model was used to assess the toxicity of ingested mDTEB-labeled CNFs. Zebrafish (

Indexed as

cellulose nanomaterialsfluorescencetoxicitytrace labeling

Identifiers

PMID33921179
PMCPMC8071547
OpenAlexW3155556457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.