Evidence map›Paper›PMID 33921170›Full record

ReviewMolecules (Basel, Switzerland)2021

Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action.

Lais Pessanha de Carvalho, Andrea Kreidenweiss, Jana Held

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Prescription-only medicine requests by clients: Insights from community pharmacies.Exploratory research in clinical and social pharmacy · 2026
    Article
  2. Review
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  4. Review
  5. Article
  6. Review
  7. Article
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  10. Apicoplast-Resident Processes: Exploiting the Chink in the Armour ofAdvances in pharmacological and pharmaceutical sciences · 2024
    Review
  11. Identification and Validation ofMicroorganisms · 2022
    Article
  12. Can repurposing drugs play a role in malaria control?The Journal of experimental medicine · 2021
    Article
  13. Article
  14. Multipurpose Drugs Active Against BothFrontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Lais Pessanha de CarvalhoInstitute of Tropical Medicine, University of Tuebingen, 72074 Tuebingen, Germany.
Andrea KreidenweissInstitute of Tropical Medicine, University of Tuebingen, 72074 Tuebingen, Germany.ORCID 0000-0002-5025-7221
Jana HeldInstitute of Tropical Medicine, University of Tuebingen, 72074 Tuebingen, Germany.
Centre de Recherche Médicales de Lambaréné · GAUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is one of the most life-threatening infectious diseases and constitutes a major health problem, especially in Africa. Although artemisinin combination therapies remain efficacious to treat malaria, the emergence of resistant parasites emphasizes the urgent need of new alternative chemotherapies. One strategy is the repurposing of existing drugs. Herein, we reviewed the antimalarial effects of marketed antibiotics, and described in detail the fast-acting antibiotics that showed activity in nanomolar concentrations. Antibiotics have been used for prophylaxis and treatment of malaria for many years and are of particular interest because they might exert a different mode of action than current antimalarials, and can be used simultaneously to treat concomitant bacterial infections.

Indexed as

AnimalsAnti-Bacterial AgentsAntimalarialsDrug RepositioningDrug ResistanceHumansMalariaPlasmodium falciparumAnti-Bacterial AgentsAntimalarialsantibioticsdrug repurposingmalariaPlasmodiumslow and fast-acting drugs

Identifiers

PMID33921170
PMCPMC8071546
OpenAlexW3155196938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.