Evidence map›Paper›PMID 33921138›Full record

SynthesisInternational journal of environmental research and public health2021

Health Risks of Structural Firefighters from Exposure to Polycyclic Aromatic Hydrocarbons: A Systematic Review and Meta-Analysis.

Jooyeon Hwang, Chao Xu, Robert J Agnew, Shari Clifton, Tara R Malone

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Development and Evaluation of the Firefighter Exposure to Carcinogens Scale.Journal of occupational and environmental medicine · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Assessment of Volatile Compound Transference through Firefighter Turnout Gear.International journal of environmental research and public health · 2022
    Article
  14. Article
  15. Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters.International journal of environmental research and public health · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jooyeon HwangDepartment of Occupational and Environmental Health, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-2416-1138
Chao XuDepartment of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-3821-6187
Robert J AgnewFire Protection & Safety Engineering Technology Program, College of Engineering, Architecture and Technology, Oklahoma State University, Stillwater, OK 74078, USA.ORCID 0000-0002-1964-2594
Shari CliftonDepartment of Health Sciences Library and Information Management, Graduate College, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0003-0743-8198
Tara R MaloneDepartment of Health Sciences Library and Information Management, Graduate College, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-1998-3532

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Robert Hal Scofield · 2013 to 2026
$68.2M
Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Wade Williams · 2018 to 2026
$27.1M
Effects of residual PAH exposure from firefighters' turnout gear on plasma microRNA expressionK01OH011891 · OH · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HWANG, JOOYEON · 2020 to 2022
$432k
NCI NIH HHS P30 CA225520NIGMS NIH HHS U54 GM104938NIOSH CDC HHS K01 OH011891
6 · The paper itself

Abstract

Firefighters have an elevated risk of cancer, which is suspected to be caused by occupational and environmental exposure to fire smoke. Among many substances from fire smoke contaminants, one potential source of toxic exposure is polycyclic aromatic hydrocarbons (PAH). The goal of this paper is to identify the association between PAH exposure levels and contributing risk factors to derive best estimates of the effects of exposure on structural firefighters' working environment in fire. We surveyed four databases (Embase, Medline, Scopus, and Web of Science) for this systematic literature review. Generic inverse variance method for random effects meta-analysis was applied for two exposure routes-dermal and inhalation. In dermal, the neck showed the highest dermal exposure increased after the fire activity. In inhalation, the meta-regression confirmed statistically significant increases in PAH concentrations for longer durations. We also summarized the scientific knowledge on occupational exposures to PAH in fire suppression activities. More research into uncontrolled emergency fires is needed with regard to newer chemical classes of fire smoke retardant and occupational exposure pathways. Evidence-based PAH exposure assessments are critical for determining exposure-dose relationships in large epidemiological studies of occupational risk factors.

Indexed as

Air Pollutants, OccupationalFirefightersFiresOccupational ExposurePolycyclic Aromatic HydrocarbonsHumansAir Pollutants, OccupationalPolycyclic Aromatic Hydrocarbonsfirefightermeta-analysisoccupational exposurepolycyclic aromatic hydrocarbonssystematic review

Identifiers

PMID33921138
PMCPMC8071552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.