Evidence map›Paper›PMID 33921056›Full record

ArticleMolecules (Basel, Switzerland)2021

Quorum Sensing and NF-κB Inhibition of Synthetic Coumaperine Derivatives from

Yael Kadosh, Subramani Muthuraman, Karin Yaniv, Yifat Baruch, Jacob Gopas, Ariel Kushmaro, Rajendran Saravana Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. NF-Journal of immunology research · 2025
    Article
  2. Biofilm · 2024
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yael KadoshAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben Gurion University of the Negev, Be'er Sheva 8410501, Israel.
Subramani MuthuramanChemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai 600127, India.
Karin YanivAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben Gurion University of the Negev, Be'er Sheva 8410501, Israel.ORCID 0000-0003-4063-0915
Yifat BaruchAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben Gurion University of the Negev, Be'er Sheva 8410501, Israel.
Jacob GopasDepartment of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Be'er Sheva 8410501, Israel.ORCID 0000-0001-9289-8898
Ariel KushmaroAvram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben Gurion University of the Negev, Be'er Sheva 8410501, Israel.ORCID 0000-0002-1970-9656
Rajendran Saravana KumarChemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai 600127, India.ORCID 0000-0002-7440-4038
Ben-Gurion University of the Negev · ILVellore Institute of Technology University · IN

Funding

Ben-Gurion University of the Negev None
6 · The paper itself

Abstract

Bacterial communication, termed Quorum Sensing (QS), is a promising target for virulence attenuation and the treatment of bacterial infections. Infections cause inflammation, a process regulated by a number of cellular factors, including the transcription Nuclear Factor kappa B (NF-κB); this factor is found to be upregulated in many inflammatory diseases, including those induced by bacterial infection. In this study, we tested 32 synthetic derivatives of coumaperine (CP), a known natural compound found in pepper (

Indexed as

Quorum SensingAnti-Bacterial AgentsNF-kappa BPiperidinesPiper nigrumAnti-Bacterial AgentscoumaperineNF-kappa BPiperidinesamide alkaloidsantibacterialcoumaperineNF-kBPiper nigrumplant natural-based compoundsquorum sensing

Identifiers

PMID33921056
PMCPMC8071387
OpenAlexW3153517921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.