Evidence map›Paper›PMID 33921050›Full record

ArticleInternational journal of molecular sciences2021

Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis.

Sukkum Ngullie Chang, Imran Khan, Chang Geon Kim, Seon Min Park, Dong Kyu Choi, Heejin Lee, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Sukkum Ngullie ChangAdvanced Bio Convergence Center (ABCC), Pohang Technopark Foundation, Pohang, Gyeongbuk 37668, Korea.
Imran KhanDepartment of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 38453, Korea.
Chang Geon KimAdvanced Bio Convergence Center (ABCC), Pohang Technopark Foundation, Pohang, Gyeongbuk 37668, Korea.
Seon Min ParkAdvanced Bio Convergence Center (ABCC), Pohang Technopark Foundation, Pohang, Gyeongbuk 37668, Korea.
Dong Kyu ChoiNew Drug Development Center, DGMIF, 88 Dongnae-ro, Dong-gu, Daegu 41061, Korea.ORCID 0000-0002-6379-3074
Heejin LeeNew Drug Development Center, DGMIF, 88 Dongnae-ro, Dong-gu, Daegu 41061, Korea.ORCID 0000-0001-8903-8520
Buyng Su HwangNakdonggang National Institute of Biological Resources, Sangju 37242, Korea.ORCID 0000-0002-6774-7294
Sun Chul KangDepartment of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 38453, Korea.
Jae Gyu ParkAdvanced Bio Convergence Center (ABCC), Pohang Technopark Foundation, Pohang, Gyeongbuk 37668, Korea.ORCID 0000-0001-6757-0241
Pohang TechnoPark (South Korea) · KRDaegu-Gyeongbuk Medical Innovation Foundation · KRDaegu University · KRNational Institute of Biological Resources · KRUniversity of Minnesota · US

Funding

Ministry of SMEs and Startups (S2983880)
6 · The paper itself

Abstract

Melanoma is known to aggressively metastasize and is one of the prominent causes of skin cancer mortality. This study was designed to assess the molecular mechanism of decursinol angelate (DA) against murine melanoma cell line (B16F10 cells). Treatment of DA resulted in growth inhibition and cell cycle arrest at G0/G1 (

Indexed as

ApoptosisAcetylcysteineAnimalsAntineoplastic AgentsAutophagosomesBenzopyransButyratesCell Cycle CheckpointsCell Line, TumorCell ProliferationHumansMaleMelanomaMelanoma, ExperimentalMiceMice, Inbred BALB CAcetylcysteineAntineoplastic AgentsBenzopyransButyratesdecursinReactive Oxygen SpeciesapoptosisB16F10 murine melanoma cellscell cycledecursinol angelate (DA)reactive oxygen species (ROS)

Identifiers

PMID33921050
PMCPMC8071397
OpenAlexW3154793024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.