ArticlePharmaceutics2021
In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers.
Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 102 citations in OpenAlex.
- Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity ofDrug delivery · 2026Article
- Dual mucoadhesive nanoparticle-hydrogel platform for sustained intravaginal miconazole delivery with anti-biofilm activity against vulvovaginal candidiasis.Drug delivery and translational research · 2026Article
- Development of Mucoadhesive Nanofiber as an Alternate Therapeutic Regimen for Subclinical Endometritis in Cattle.Turkish journal of pharmaceutical sciences · 2026Article
- Stimuli-Responsive Crosslinked Chitosan/PVP/PEG Hydrogel Networks for Targeted Drug Delivery and Antimicrobial Performance.Analytical science advances · 2026Article
- Bio-degradable electrospun nanofibers encompassing dioxidovanadium benzimidazole compounds as potential drug delivery systems for diabetes mellitus.RSC advances · 2026Article
- Mucoadhesive nanofibers for ocular drug delivery: mechanisms, design strategies, and applications.Drug delivery and translational research · 2026Review
- Biosynthesis and characterization of zinc oxide nanoparticles using Dennettia tripetala for the antioxidant and drug release potentials.Scientific reports · 2025Article
- Machine Learning-Guided Prediction of Formulation Performance in Inhalable Ciprofloxacin-Bile Acid Dispersions with Antimicrobial and Toxicity Evaluation.Molecular pharmaceutics · 2025Article
- FeACS omega · 2025Article
- Fabrication and characterization of polysaccharide-based microspheres for ciprofloxacin delivery with controlled release and antimicrobial activity.RSC advances · 2025Article
- Innovative Wound Healing Strategy Through Amorphization of Active Pharmaceutical Ingredients as an Effective Approach for Hydrogel Formulation.Pharmaceuticals (Basel, Switzerland) · 2025Review
- In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria.Nature communications · 2025Article
- Diclofenac-Loaded Orodispersible Nanofibers Prepared by Double-Needle Electrospinning.Polymers · 2025Article
- Ciprofloxacin-Loaded Spray-Dried Lactose Particles: Formulation Optimization and Antibacterial Efficacy.Pharmaceutics · 2025Article
- Multifunctional polymeric nanofibrous scaffolds enriched with azilsartan medoxomil for enhanced wound healing.Drug delivery and translational research · 2025Article
- BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: AnCurrent research in pharmacology and drug discovery · 2025Article
- pH-Responsive Deacetylated Sphingan WL Gum-Based Microgels for the Oral Delivery of Ciprofloxacin Hydrochloride.ACS omega · 2024Article
- Ciprofloxacin- and levofloxacin-loaded nanoparticles efficiently suppressed fluoroquinolone resistance and biofilm formation in Acinetobacter baumannii.Scientific reports · 2024Article
- Drug Loaded 3D-Printed Poly(ε-Caprolactone) Scaffolds for Local Antibacterial or Anti-Inflammatory Treatment in Bone Regeneration.Polymers · 2023Article
- Reinforcement of Acrylamide Hydrogels with Cellulose Nanocrystals Using Gamma Radiation for Antibiotic Drug Delivery.Gels (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Nanofibers of the poorly water-soluble antibiotic ciprofloxacin (CIP) were fabricated in the form of an amorphous solid dispersion by using poly(vinyl pyrrolidone) as a polymer matrix, by the low-cost electrospinning method. The solubility of the nanofibers as well as their in vitro diffusion were remarkably higher than those of the CIP powder or the physical mixture of the two components. The fiber size and morphology were optimized, and it was found that the addition of the CIP to the electrospinning solution decreased the nanofiber diameter, leading to an increased specific surface area. Structural characterization confirmed the interactions between the drug and the polymer and the amorphous state of CIP inside the nanofibers. Since the solubility of CIP is pH-dependent, the in vitro solubility and dissolution studies were executed at different pH levels. The nanofiber sample with the finest morphology demonstrated a significant increase in solubility both in water and pH 7.4 buffer. Single medium and two-stage biorelevant dissolution studies were performed, and the release mechanism was described by mathematical models. Besides, in vitro diffusion from pH 6.8 to pH 7.4 notably increased when compared with the pure drug and physical mixture. Ciprofloxacin-loaded poly(vinyl pyrrolidone) (PVP) nanofibers can be considered as fast-dissolving formulations with improved physicochemical properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.