Evidence map›Paper›PMID 33920855›Full record

ReviewFoods (Basel, Switzerland)2021

A Narrative Review on Dietary Strategies to Provide Nitric Oxide as a Non-Drug Cardiovascular Disease Therapy: Beetroot Formulations-A Smart Nutritional Intervention.

Diego Dos Santos Baião, Davi Vieira Teixeira da Silva, Vania Margaret Flosi Paschoalin

Open access · goldAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Gas entrapping materials for damage control.Advanced drug delivery reviews · 2026
    Review
  2. Article
  3. Review
  4. Can Beetroot (Nutrients · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Diego Dos Santos BaiãoChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitaria, Rio de Janeiro, RJ 21941-909, Brazil.
Davi Vieira Teixeira da SilvaChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitaria, Rio de Janeiro, RJ 21941-909, Brazil.
Vania Margaret Flosi PaschoalinChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Cidade Universitaria, Rio de Janeiro, RJ 21941-909, Brazil.ORCID 0000-0001-6093-134X
Universidade Federal do Rio de Janeiro · BR

Funding

Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 1627392Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.254/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.345/2019Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.815/2018
6 · The paper itself

Abstract

Beetroot is a remarkable vegetable, as its rich nitrate and bioactive compound contents ameliorate cardiovascular and metabolic functions by boosting nitric oxide synthesis and regulating gene expressions or modulating proteins and enzyme activities involved in these cellular processes. Dietary nitrate provides a physiological substrate for nitric oxide production, which promotes vasodilatation, increases blood flow and lowers blood pressure. A brief narrative and critical review on dietary nitrate intake effects are addressed herein by considering vegetable sources, dosage, intervention regimen and cardioprotective effects achieved in both healthy and cardiovascular-susceptible individuals. Compared to other nitrate-rich vegetables, beets were proven to be the best choice for non-drug therapy because of their sensorial characteristics and easy formulations that facilitate patient adherence for long periods, allied to bioaccessibility and consequent effectiveness. Beets were shown to be effective in raising nitrate and nitrite in biological fluids at levels capable of promoting sustained improvement in primary and advanced hemodynamic parameters.

Indexed as

advanced hemodynamic parametersbeetrootclinical trialsgreen leavesnitrate-rich diet therapynitric oxide

Identifiers

PMID33920855
PMCPMC8071323
OpenAlexW3154674326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.