Evidence map›Paper›PMID 33920813›Full record

ArticleMetabolites2021

Serum Zinc, Copper, and Other Biometals Are Associated with COVID-19 Severity Markers.

Anatoly V Skalny, Peter S Timashev, Michael Aschner, Jan Aaseth, Lyubov N Chernova, Vladimir E Belyaev, Andrey R Grabeklis, Svetlana V Notova, Ryszard Lobinski, Aristides Tsatsakis and 4 more

Abstract read
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. COVID-19 and Selenium Deficiency: a Systematic Review.Biological trace element research · 2022
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Review
  9. Observational
  10. Article
  11. Review
  12. Article
  13. Article
  14. Zinc and selenium status in coronavirus disease 2019.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anatoly V SkalnyWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Peter S TimashevWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Michael AschnerWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.ORCID 0000-0002-2619-1656
Jan AasethWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.ORCID 0000-0002-7518-5703
Lyubov N ChernovaWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Vladimir E BelyaevWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Andrey R GrabeklisWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Svetlana V NotovaWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Ryszard LobinskiWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Aristides TsatsakisWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.ORCID 0000-0003-3824-2462
Andrey A SvistunovWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Victor V FominWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Alexey A TinkovWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.
Peter V GlybochkoWorld-Class Research Center "Digital Biodesign and Personalized Healthcare", IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation 075-15-2020-926
6 · The paper itself

Abstract

The objective of the present study was to evaluate of serum metal levels in COVID-19 patients with different disease severity, and to investigate the independent association between serum metal profile and markers of lung damage. The cohort of COVID-19 patients consisted of groups of subjects with mild, moderate, and severe illness, 50 examinees each. Forty-four healthy subjects of the respective age were involved in the current study as the control group. Serum metal levels were evaluated using inductively-coupled plasma mass-spectrometry. Examination of COVID-19 patients demonstrated that heart rate, respiratory rate, body temperature, C-reactive protein levels, as well as lung damage increased significantly with COVID-19 severity, whereas SpO

Indexed as

ironlung damagenovel coronavirus infectionseleniumtrace elements

Identifiers

PMID33920813
PMCPMC8071197

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.