Evidence map›Paper›PMID 33920796›Full record

ReviewJournal of clinical medicine2021

Frailty in Acute and Chronic Coronary Syndrome Patients Entering Cardiac Rehabilitation.

Francesco Giallauria, Anna Di Lorenzo, Elio Venturini, Mario Pacileo, Antonello D'Andrea, Umberto Garofalo, Felice De Lucia, Crescenzo Testa, Gianluigi Cuomo, Gabriella Iannuzzo and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Outpatients' cardiac rehabilitation: the long-term experience of the Niguarda Hospital.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. ITACARE-P/SIGG/SIGOT/SICGE position paper on elderly cardiac patient referral to cardiac rehabilitation.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Cardio-oncology rehabilitation: are we ready?European heart journal supplements : journal of the European Society of Cardiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Francesco GiallauriaDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0003-4119-9397
Anna Di LorenzoDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.
Elio VenturiniCardiac Rehabilitation Unit, Azienda USL Toscana Nord-Ovest, Cecina Civil Hospital, 57023 Cecina (LI), Italy.ORCID 0000-0001-7223-7574
Mario PacileoDivision of Cardiology/UTIC, "Umberto I" Hospital, Nocera Inferiore (ASL Salerno), 84014 Nocera Inferiore (SA), Italy.ORCID 0000-0002-6330-1738
Antonello D'AndreaDivision of Cardiology/UTIC, "Umberto I" Hospital, Nocera Inferiore (ASL Salerno), 84014 Nocera Inferiore (SA), Italy.ORCID 0000-0002-9698-9145
Umberto GarofaloDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0002-5864-7064
Felice De LuciaDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.
Crescenzo TestaDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0002-8360-5173
Gianluigi CuomoDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.
Gabriella IannuzzoDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0002-7392-5544
Marco GentileDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80131 Naples, Italy.ORCID 0000-0003-3744-6375
Cinzia NugaraCardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy.ORCID 0000-0001-9415-2360
Filippo M SarulloCardiovascular Rehabilitation Unit, Buccheri La Ferla Fatebenefratelli Hospital, 90123 Palermo, Italy.ORCID 0000-0003-2046-8316
Nastasia MarinusREVAL-Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, BE3590 Diepenbeek, Belgium.ORCID 0000-0002-4903-2439
Dominique HansenREVAL-Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, BE3590 Diepenbeek, Belgium.
Carlo VigoritoDepartment of Translational Medical Sciences, "Federico II" University of Naples, 80131 Naples, Italy.
University of Naples Federico II · ITFatebenefratelli Hospital · ITAzienda Usl Toscana Centro · ITHasselt University · BEJessa Hospital · BEOspedali Riuniti Umberto I · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide population ageing is partly due to advanced standard of care, leading to increased incidence and prevalence of geriatric syndromes such as frailty and disability. Hence, the age at the onset of acute coronary syndromes (ACS) keeps growing as well. Moreover, ageing is a risk factor for both frailty and cardiovascular disease (CVD). Frailty and CVD in the elderly share pathophysiological mechanisms and associated conditions, such as malnutrition, sarcopenia, anemia, polypharmacy and both increased bleeding/thrombotic risk, leading to a negative impact on outcomes. In geriatric populations ACS is associated with an increased frailty degree that has a negative effect on re-hospitalization and mortality outcomes. Frail elderly patients are increasingly referred to cardiac rehabilitation (CR) programs after ACS; however, plans of care must be tailored on individual's clinical complexity in terms of functional capacity, nutritional status and comorbidities, cognitive status, socio-economic support. Completing rehabilitative intervention with a reduced frailty degree, disability prevention, improvement in functional state and quality of life and reduction of re-hospitalization are the goals of CR program. Tools for detecting frailty and guidelines for management of frail elderly patients post-ACS are still debated. This review focused on the need of an early identification of frail patients in elderly with ACS and at elaborating personalized plans of care and secondary prevention in CR setting.

Indexed as

acute coronary syndromecardiac rehabilitationcardiovascular diseasechronic coronary syndromeexercise trainingfrailty

Identifiers

PMID33920796
PMCPMC8071180
OpenAlexW3154433450

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.