Evidence map›Paper›PMID 33920645›Full record

ArticleLife (Basel, Switzerland)2021

The Impact of Lifetime Alcohol and Cigarette Smoking Loads on Amyotrophic Lateral Sclerosis Progression: A Cross-Sectional Study.

Aliona Cucovici, Andrea Fontana, Andrei Ivashynka, Sergio Russo, Valentina Renna, Letizia Mazzini, Ileana Gagliardi, Jessica Mandrioli, Ilaria Martinelli, Vitalie Lisnic and 4 more

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Amyotrophic Lateral Sclerosis: A Diet Review.Foods (Basel, Switzerland) · 2021
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aliona CucoviciDepartment of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0003-3412-0628
Andrea FontanaUnit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Andrei IvashynkaNeurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0003-0840-1872
Sergio RussoICT Innovation & Research Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-8773-8651
Valentina RennaNeurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Letizia MazziniDepartment of Neurology and ALS Centre, University of Piemonte Orientale, Maggiore della Carità Hospital, 28100 Novara, Italy.
Ileana GagliardiDepartment of Neurology and ALS Centre, University of Piemonte Orientale, Maggiore della Carità Hospital, 28100 Novara, Italy.
Jessica MandrioliNeurology Unit, Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.ORCID 0000-0002-9244-9782
Ilaria MartinelliNeurology Unit, Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, 41125 Modena, Italy.ORCID 0000-0003-2566-3671
Vitalie LisnicDepartment of Neurology, State University of Medicine and Pharmacy "Nicolae Testemitanu", 2004 Chisinau, Moldova.ORCID 0000-0002-5432-8859
Dafin Fior MuresanuDepartment of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania and "RoNeuro" Institute for Neurological Research and Diagnostic, 400000 Cluj-Napoca, Romania.
Michele ZarrelliNeurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Massimiliano CopettiUnit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Maurizio A LeoneNeurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.ORCID 0000-0002-6339-5738

Funding

Department of Translational Medicine (DIMET), Università del Piemonte Orientale, Novara, Italy AGING Project for Department of ExcellenceMinistero della Salute RC1801NE08Organisation Internationale de la Vigne et du Vin OIV Research Grant 2016
6 · The paper itself

Abstract

Background-Amyotrophic lateral sclerosis (ALS) is a devastating and untreatable motor neuron disease; smoking and alcohol drinking may impact its progression rate. Objective-To ascertain the influence of smoking and alcohol consumption on ALS progression rates. Methods-Cross-sectional multicenter study, including 241 consecutive patients (145 males); mean age at onset was 59.9 ± 11.8 years. Cigarette smoking and alcohol consumption data were collected at recruitment through a validated questionnaire. Patients were categorized into three groups according to ΔFS (derived from the ALS Functional Rating Scale-Revised and disease duration from onset): slow (

Indexed as

alcohol drinkingamyotrophic lateral sclerosisdisease progression rateprognosisquestionnairesmoking

Identifiers

PMID33920645
PMCPMC8072690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.