Evidence map›Paper›PMID 33920642›Full record

Trial reportNutrients2021

The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis.

Joseph Yusin, Vivian Wang, Susanne M Henning, Jieping Yang, Chi-Hong Tseng, Gail Thames, Irina Arnold, David Heber, Ru-Po Lee, Laura Sanavio and 3 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. [Research progress in the regulation of allergic rhinitis pathogenesis by the NRF2 pathway].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Joseph YusinDepartment of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
Vivian WangDepartment of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
Susanne M HenningDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Jieping YangDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Chi-Hong TsengDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Gail ThamesDepartment of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
Irina ArnoldDepartment of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.
David HeberDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Ru-Po LeeDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Laura SanavioDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Yajing PanDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Tianyu QinDepartment of Internal Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095, USA.
Zhaoping LiDepartment of Allergy and Immunology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA.ORCID 0000-0002-8662-4310
University of California, Los Angeles · USVA Greater Los Angeles Healthcare System · US

Funding

Office of Research and Development 2019-070565
6 · The paper itself

Abstract

Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (

Indexed as

BrassicaAdministration, IntranasalAdrenal Cortex HormonesAdultAgedAllergensCytokinesDouble-Blind MethodDrug Therapy, CombinationFemaleHumansMaleMiddle AgedNasal MucosaNasal SpraysPlant ExtractsAdrenal Cortex HormonesAllergensCytokinesNasal SpraysPlant Extractsallergen extractallergic rhinitisantioxidantbroccoli sproutglutathione transferasenasal corticosteroidpeak nasal inspiratory flowsulforaphaneT2 cytokinestotal nasal symptom score

Identifiers

PMID33920642
PMCPMC8074067
OpenAlexW3153332292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.