Evidence map›Paper›PMID 33920561›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses.

Joanna Stefan, Tae-Kang Kim, Fiona Schedel, Zorica Janjetovic, David K Crossman, Kerstin Steinbrink, Radomir M Slominski, Jaroslaw Zmijewski, Meri K Tulic, Russel J Reiter and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. The Impact of Sleep Quality on Skin Color.Indian dermatology online journal · 2025
    Article
  2. Review
  3. Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage.Biological reviews of the Cambridge Philosophical Society · 2024
    Review
  4. Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Melatonin and Kidney Health: From Fetal Stage to Later Life.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Joanna StefanDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-2205-9893
Tae-Kang KimDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Fiona SchedelDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.
Zorica JanjetovicDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
David K CrossmanDepartment of Genetics, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Kerstin SteinbrinkDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.
Radomir M SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jaroslaw ZmijewskiDepartment of Medicine, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Meri K TulicTeam 12, Centre Méditerranéen de Médecine Moléculaire (C3M), Université Côte d'Azur, INSERM U1065, 06200 Nice, France.
Russel J ReiterDepartment of Cellular and Structural Biology, UT Health Science Center, San Antonio, TX 78229, USA.ORCID 0000-0001-6763-4225
Konrad KleszczyńskiDepartment of Dermatology, University of Münster, Von-Esmarch-Str. 58, 48149 Münster, Germany.ORCID 0000-0002-1311-263X
Andrzej T SlominskiDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-8963-3995
University of Alabama at Birmingham · USUniversity of Münster · DEInserm · FRNicolaus Copernicus University · PLThe University of Texas Health Science Center at San Antonio · US

Funding

Mechanism of action and function of novel secosteroid 20(OH)D3 in the skinR01AR073004 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANDRZEJ T SLOMINSKI · 2018 to 2026
$2.9M
Significance of metabolic activation of lumisterol in the skinR01AR071189 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SLOMINSKI, ANDRZEJ T · 2017 to 2021
$1.6M
Role of Exogenous Melatonin in Skin BiologyR01AR056666 · NIAMS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SLOMINSKI, ANDRZEJ T · 2011 to 2015
$1.6M
Canonical and non-canonical vitamin D activation pathways in systemic lupusR21AI149267 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RAMAN, CHANDER, SLOMINSKI, ANDRZEJ T · 2020 to 2021
$408k
CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancerI01BX004293 · VA · BIRMINGHAM VA MEDICAL CENTER · PI SLOMINSKI, ANDRZEJ T · 2019 to 2025
–
BLRD VA I01 BX004293Deutsche Forschungsgemeinschaft KL2900/2-1NIAID NIH HHS R21 AI149267NIAMS NIH HHS R01 AR056666NIAMS NIH HHS R01 AR071189NIAMS NIH HHS R01 AR073004NIH HHS 1R01AR056666-01A2, 1R01AR073004-01A1, 1RO1AR071189-01A1 and R21AI149267-01A1VA Merit Grant 1I01BX004293-01A1
6 · The paper itself

Abstract

We investigated the effects of melatonin and its selected metabolites, i.e.,

Indexed as

human keratinocytesmelatoninmetabolites of melatoninmitochondrial metabolismRNA-sequencing

Identifiers

PMID33920561
PMCPMC8073250
OpenAlexW3154522764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.