Evidence map›Paper›PMID 33920475›Full record

ArticleMarine drugs2021

Pharmacokinetics and Pharmacodynamics of a Depolymerized Glycosaminoglycan from

Shuang Liu, Taocui Zhang, Huifang Sun, Lisha Lin, Na Gao, Weili Wang, Sujuan Li, Jinhua Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shuang LiuState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Taocui ZhangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Huifang SunState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Lisha LinState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Na GaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Weili WangState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Sujuan LiState Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
Jinhua ZhaoSchool of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Chinese Academy of Sciences · CNSouth Central University for Nationalities · CNKunming Institute of Botany · CNUniversity of Chinese Academy of Sciences · CN

Funding

National Natural Science Foundation of China 81703374National Natural Science Foundation of China 81773737Yunnan Provincial Science and Technology Department in China 2019ZF011-2
6 · The paper itself

Abstract

dHG-5 (Mw 5.3 kD) is a depolymerized glycosaminoglycan from sea cucumber

Indexed as

AnimalsBiotransformationBlood CoagulationDrug MonitoringFactor Xa InhibitorsGlycosaminoglycansHalf-LifeHolothuriaInjections, IntravenousInjections, SubcutaneousMalePartial Thromboplastin TimeRatsRats, Sprague-DawleyRenal EliminationFactor Xa InhibitorsGlycosaminoglycansanticoagulantdHG-5fucosylated glycosaminoglycanmethod validationpharmacodynamicspharmacokinetics

Identifiers

PMID33920475
PMCPMC8069088
OpenAlexW3156429820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.