ArticleCancers2021
Preoperative Inflammatory Markers as a Predictor of Three-Year Overall Survival in Older Cancer Patients Undergoing Oncologic Surgery.
Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Prehabilitation: A Catalyst for Transforming Toward Value-Based, Personalized Perioperative Health and Care.Journal of clinical medicine · 2025Article
- Dynamic Inflammatory and Nutritional Profiles in Preoperative Risk Stratification for Elderly Patients [Letter].Journal of inflammation research · 2025Article
- The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging.International journal of molecular sciences · 2024Review
- Von Willebrand Factor Antigen, Biomarkers of Inflammation, and Microvascular Flap Thrombosis in Reconstructive Surgery.Journal of clinical medicine · 2024Article
- The Association Between Intraoperative Compromised Intestinal Integrity and Postoperative Complications in Cancer Patients.Annals of surgical oncology · 2024Article
- Association between inflammation-based prognostic markers and mortality of non-cardiac surgery.Korean journal of anesthesiology · 2023Article
- Association between anaesthesia-related factors and postoperative neurocognitive disorder: a post-hoc analysis.BMC anesthesiology · 2023Observational
- Effects of systemic inflammation and frailty on survival in elderly cancer patients: Results from the INSCOC study.Frontiers in immunology · 2023Article
- Timed up and go test and long-term survival in older adults after oncologic surgery.BMC geriatrics · 2022Article
- Does Inflammation Contribute to Cancer Incidence and Mortality during Aging? A Conceptual Review.Cancers · 2022Review
- The association between the inflammatory response following surgery and post-operative delirium in older oncological patients: a prospective cohort study.Age and ageing · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncologic surgery results in substantially higher morbidity and mortality rates in older patients compared to younger patients, yet little is known about the relation between the preoperative inflammatory state and postoperative outcome in the specific group of older cancer patients. The aim of this study was to examine whether preoperative inflammatory markers could be a predictor of overall survival in older patients undergoing elective surgery for a solid malignant tumor. Patients 65 years and older undergoing surgery for a solid malignant tumor were included in a prospective cohort study. Inflammatory markers C-reactive protein (CRP), interleukin-1 beta (IL-1β), IL-6, IL10, IL-12 and tumor necrosis factor-alpha (TNF-α) were measured in plasma samples preoperatively. The main outcome was overall survival three years after surgery. Between 2010 and 2016, 328 patients with a median age of 71.5 years (range 65-89) were included. A significantly higher mortality rate three years after surgery, was found in patients with high preoperative plasma levels of CRP and IL-6 (
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