Evidence map›Paper›PMID 33920366›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Sinapic Acid Suppresses SARS CoV-2 Replication by Targeting Its Envelope Protein.

Raha Orfali, Mostafa E Rateb, Hossam M Hassan, Mona Alonazi, Mokhtar R Gomaa, Noura Mahrous, Mohamed GabAllah, Ahmed Kandeil, Shagufta Perveen, Usama Ramadan Abdelmohsen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Utilizing sinapic acid as an inhibitory antiviral agent against MERS-CoV PLpro.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?Archivum immunologiae et therapiae experimentalis · 2023
    Article
  10. Article
  11. COVID-19 Therapeutic Potential of Natural Products.International journal of molecular sciences · 2023
    Review
  12. Review
  13. SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  14. Review
  15. Green Synthesized Zinc Oxide Nanoparticles Based onMolecules (Basel, Switzerland) · 2022
    Article
  16. Review
  17. Article
  18. New Halogenated Compounds fromMolecules (Basel, Switzerland) · 2022
    Article
  19. Wound Healing and Antioxidant Capabilities ofPlants (Basel, Switzerland) · 2022
    Article
  20. Viroporins: Structure, function, and their role in the life cycle of SARS-CoV-2.The international journal of biochemistry & cell biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Raha OrfaliDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.
Mostafa E RatebSchool of Computing, Engineering & Physical Sciences, University of the West of Scotland, Paisley PA1 2BE, UK.ORCID 0000-0003-4043-2687
Hossam M HassanDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.
Mona AlonaziDepartment of Biochemistry, Faculty of Science, King Saud University. P.O. Box 12372, Riyadh 11495, Saudi Arabia.ORCID 0000-0002-9430-7980
Mokhtar R GomaaCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza 12622, Egypt.
Noura MahrousCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza 12622, Egypt.
Mohamed GabAllahCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza 12622, Egypt.
Ahmed KandeilCenter of Scientific Excellence for Influenza Virus, Environmental Research Division, National Research Centre, Giza 12622, Egypt.ORCID 0000-0003-3253-6961
Shagufta PerveenDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.ORCID 0000-0002-3318-9861
Usama Ramadan AbdelmohsenDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0002-1014-6922
Ahmed M SayedDepartment of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt.ORCID 0000-0002-1442-183X
National Research Centre · EGKing Saud University · SABeni-Suef University · EGDeraya UniversityNahda University · EGUniversity of the West of Scotland · GB

Funding

the Saudi Ministry of Health, Kingdom of Saudi Arabia contract number 11492700006 - project number 492
6 · The paper itself

Abstract

SARS CoV-2 is still considered a global health issue, and its threat keeps growing with the emergence of newly evolved strains. Despite the success in developing some vaccines as a protective measure, finding cost-effective treatments is urgent. Accordingly, we screened a number of phenolic natural compounds for their in vitro anti-SARS CoV-2 activity. We found sinapic acid (SA) selectively inhibited the viral replication in vitro with an half-maximal inhibitory concentration (IC

Indexed as

COVID-19molecular dynamic simulationSARS CoV-2sinapic acidviral envelope protein

Identifiers

PMID33920366
PMCPMC8069661
OpenAlexW3155208365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.