Evidence map›Paper›PMID 33920327›Full record

ArticlePharmaceutics2021

Resveratrol-Loaded Hydrogel Contact Lenses with Antioxidant and Antibiofilm Performance.

María Vivero-Lopez, Andrea Muras, Diana Silva, Ana Paula Serro, Ana Otero, Angel Concheiro, Carmen Alvarez-Lorenzo

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

María Vivero-LopezDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-7438-6458
Andrea MurasDepartamento de Microbiología, Facultad de Biología, Edificio CIBUS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0003-1603-9762
Diana SilvaCentro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Ana Paula SerroCentro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.ORCID 0000-0002-6179-9296
Ana OteroDepartamento de Microbiología, Facultad de Biología, Edificio CIBUS, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-3315-5709
Angel ConcheiroDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0003-0507-049X
Carmen Alvarez-LorenzoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-8546-7085
Universidade de Santiago de Compostela · ESUniversity of Lisbon · PT

Funding

Agencia Estatal de Investigación AEIConsellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia ED431C 2020/17Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia ED481A-2019/120European Regional Development Fund FEDERFundação para a Ciência e a Tecnologia UIDB/00100/2020Fundação para a Ciência e a Tecnologia UIDB/04585/2020Ministerio de Economía, Industria y Competitividad, Gobierno de España SAF2017-83118-R
6 · The paper itself

Abstract

Contact lenses (CLs) are prone to biofilm formation, which may cause severe ocular infections. Since the use of antibiotics is associated with resistance concerns, here, two alternative strategies were evaluated to endow CLs with antibiofilm features: copolymerization with the antifouling monomer 2-methacryloyloxyethyl phosphorylcholine (MPC) and loading of the antioxidant resveratrol with known antibacterial activity. MPC has, so far, been used to increase water retention on the CL surface (Proclear

Indexed as

antibiofilmantioxidantdevice-related ocular infectionsdrug-eluting contact lensesendophthalmitismicrobial keratitis

Identifiers

PMID33920327
PMCPMC8069945
OpenAlexW3156009602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.