Trial reportNutrients2021
A Randomized Study of Nutritional Supplementation in Patients with Unilateral Wet Age-Related Macular Degeneration.
Open access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals.Circulation. Arrhythmia and electrophysiology · 2026Pooled it
- Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.The Cochrane database of systematic reviews · 2023Pooled it
- What did we learn in 35 years of research on nutrition and supplements for age-related macular degeneration: a systematic review.Acta ophthalmologica · 2022Pooled it
- Iontophoresis Drug Delivery to the Macula of Lutein for Age Related Macular Degeneration.Diseases (Basel, Switzerland) · 2026Review
- Novel Ingredients: Hydroxytyrosol as a Neuroprotective Agent; What Is New on the Horizon?Foods (Basel, Switzerland) · 2025Review
- Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications.Molecular nutrition & food research · 2025Review
- Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA): A Targeted Antioxidant Strategy to Counter Oxidative Stress in Retinopathy.Antioxidants (Basel, Switzerland) · 2024Review
- An Overview on the Effects of Some Carotenoids on Health: Lutein and Zeaxanthin.Current nutrition reports · 2024Review
- (Photo)toxicity of Partially Oxidized Docosahexaenoate and Its Effect on the Formation of Lipofuscin in Cultured Human Retinal Pigment Epithelial Cells.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases.International journal of molecular sciences · 2024Review
- Insights into the nutritional prevention of macular degeneration based on a comparative topic modeling approach.PeerJ. Computer science · 2024Article
- Effect of supplementation with lutein, zeaxanthin, and omega-3 fatty acids on macular pigment and visual function in young adults with long-term use of digital devices: study protocol for a randomized double-blind placebo-controlled study.Frontiers in nutrition · 2024Article
- Oxidative Stress and Antioxidants in Age-Related Macular Degeneration.Antioxidants (Basel, Switzerland) · 2023Review
- Epigenetic modifications and metabolic memory in diabetic retinopathy: beyond the surface.Neural regeneration research · 2023Review
- Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA.Scientific reports · 2023Article
- Review
- The Role of Oxidative Stress in the Aging Eye.Life (Basel, Switzerland) · 2023Review
- Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2022Review
- Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease.Nutrients · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 2 countries.
Alfredo García-LayanaRetinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Av. de Pío XII, 36, 31008 Pamplona, Spain.
Sergio RecaldeRetinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Av. de Pío XII, 36, 31008 Pamplona, Spain.ORCID 0000-0002-9328-9725
Maria HernandezRetinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Av. de Pío XII, 36, 31008 Pamplona, Spain.
Maximino J AbraldesRed Temática de Investigación Cooperativa Sanitaria en Enfer-Medades Oculares (Oftared), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain.
João NascimentoRetinal Department, Ophthalmology, Retina Lisbon Institut, Av. Duque de Loulé Nº5, 1050-085 Lisbon, Portugal.
Emiliano Hernández-GalileaDepartment of Ophthalmology, University of Salamanca, University Hospital of Salamanca, Paseo de San Vicente 182, 37007 Salamanca, Spain.ORCID 0000-0002-5927-0836
Begoña Olmedilla-AlonsoDepartment of Metabolism and Nutrition, Institute of Food Science, Technology and Nutrition (ICTAN-CSIC), José Antonio Novais 10, 28040 Madrid, Spain.ORCID 0000-0002-4913-5171
Jose Juan Escobar-BarrancoDepartment of Ophthalmology, Hospital Dos de Maig, Carrer del Dos de Maig 301, 08025 Barcelona, Spain.
Miguel Angel ZapataDepartment of Ophthalmology, Hospital Vall Hebron, Passeig de la Vall d'Hebron 119, 08035 Barcelona, Spain.
Rufino SilvaFaculty of Medicine, Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Paço das Escolas, 3004-531 Coimbra, Portugal.ORCID 0000-0001-8676-0833
Mariana Caballero ArredondoNutrition, Food Science and Gastronomy, University of Barcelona, Joan XXIII, 27-31, 08028 Barcelona, Spain.ORCID 0000-0003-1873-3977
María Carmen Lopez-SabaterNutrition, Food Science and Gastronomy, University of Barcelona, Joan XXIII, 27-31, 08028 Barcelona, Spain.ORCID 0000-0002-8670-7044
Silvia Mendez-MartínezDepartment of Ophthalmology, Miguel Servet University Hospital, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain.ORCID 0000-0001-6072-1545
Nieves Pardiñas-BarónDepartment of Ophthalmology, Miguel Servet University Hospital, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain.
Pilar CalvoDepartment of Ophthalmology, Miguel Servet University Hospital, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain.
Patricia Fernández-RobredoRetinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Av. de Pío XII, 36, 31008 Pamplona, Spain.
Instituto de Salud Carlos III · ESUniversidad de Zaragoza · ESUniversitat de Barcelona · ESHospitais da Universidade de Coimbra · PTInstituto de Ciencia y Tecnología de Alimentos y Nutrición · ESUniversidad de Salamanca · ESUniversidade de Santiago de Compostela · ESVall d'Hebron Hospital Universitari · ES
Funding
The research was funded by Laboratorios Théa (Barcelona, Spain) and by research grants from the "Instituto de Salud Carlos III/European Regional Development Fund (ERDF)" and RD16/0008/0011, OFTARED: Enfermedades oculares: "Prevención, detección precoz, tr Not applicable
Abstract
The purpose of this study is evaluate the efficacy and safety of medicinal products containing the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group;
Indexed as
AgedAged, 80 and overDietary SupplementsDocosahexaenoic AcidsFemaleHumansLuteinMacular DegenerationMaleMiddle AgedNutrientsPhenylethyl AlcoholResveratrolTreatment OutcomeVisual AcuityXanthophylls3,4-dihydroxyphenylethanolDocosahexaenoic AcidsLuteinNutrientsPhenylethyl AlcoholResveratrolXanthophyllsZeaxanthinsage-related macular degenerationangiogenic factors at month 12AREDScarotenoidsinflammatory markerspolyunsaturated fatty acidsRetilut®Theavit®
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.