Evidence map›Paper›PMID 33919962›Full record

ArticleSensors (Basel, Switzerland)2021

A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.

Tobias Wieland, Julia Assmann, Astrid Bethe, Christian Fidelak, Helena Gmoser, Traute Janßen, Krishan Kotthaus, Antina Lübke-Becker, Lothar H Wieler, Gerald A Urban

Open access · goldAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Sensor system for analysis of biofilm sensitivity to ampicillin.Applied microbiology and biotechnology · 2024
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tobias WielandDepartment of Microsystems Engineering (IMTEK)-Laboratory of Sensors, University of Freiburg, 79110 Freiburg, Germany.ORCID 0000-0003-2930-4617
Julia AssmannInstitute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany.
Astrid BetheInstitute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany.
Christian FidelakBovicare GmbH, 14473 Potsdam, Germany.
Helena GmoserDepartment of Microsystems Engineering (IMTEK)-Laboratory of Sensors, University of Freiburg, 79110 Freiburg, Germany.
Traute JanßenRIPAC-Labor GmbH, 14476 Potsdam-Golm, Germany.
Krishan KotthausDepartment of Microsystems Engineering (IMTEK)-Laboratory of Sensors, University of Freiburg, 79110 Freiburg, Germany.
Antina Lübke-BeckerInstitute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany.
Lothar H WielerInstitute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany.
Gerald A UrbanDepartment of Microsystems Engineering (IMTEK)-Laboratory of Sensors, University of Freiburg, 79110 Freiburg, Germany.
University of Freiburg · DEFreie Universität Berlin · DERobert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing rate of antimicrobial resistance (AMR) in pathogenic bacteria is a global threat to human and veterinary medicine. Beyond antibiotics, antimicrobial peptides (AMPs) might be an alternative to inhibit the growth of bacteria, including AMR pathogens, on different surfaces. Biofilm formation, which starts out as bacterial adhesion, poses additional challenges for antibiotics targeting bacterial cells. The objective of this study was to establish a real-time method for the monitoring of the inhibition of (a) bacterial adhesion to a defined substrate and (b) biofilm formation by AMPs using an innovative thermal sensor. We provide evidence that the thermal sensor enables continuous monitoring of the effect of two potent AMPs, protamine and OH-CATH-30, on surface colonization of bovine mastitis-associated

Indexed as

Anti-Bacterial AgentsBacterial AdhesionAnimalsBiofilmsCattleEscherichia coliFemaleHumansMicrobial Sensitivity TestsPore Forming Cytotoxic ProteinsAnti-Bacterial AgentsPore Forming Cytotoxic ProteinsAMPsmeasurement in real timethermal biosensorwhite light interferometry

Identifiers

PMID33919962
PMCPMC8070953
OpenAlexW3153300510

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.