Evidence map›Paper›PMID 33919940›Full record

ArticleInternational journal of molecular sciences2021

Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition and Remodeling in Adult Mice with

Leticia Rubio, Antonio Vargas, Patricia Rivera, Antonio J López-Gambero, Rubén Tovar, Julian K Christians, Stella Martín-de-Las-Heras, Fernando Rodríguez de Fonseca, Julie A Chowen, Jesús Argente and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Leticia RubioDepartamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0002-8233-624X
Antonio VargasUnidad de Gestión Clínica de Salud Mental, IBIMA, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Patricia RiveraUnidad de Gestión Clínica de Salud Mental, IBIMA, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.ORCID 0000-0002-0478-6667
Antonio J López-GamberoUnidad de Gestión Clínica de Salud Mental, IBIMA, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.ORCID 0000-0001-7716-9056
Rubén TovarUnidad de Gestión Clínica de Salud Mental, IBIMA, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Julian K ChristiansDepartment of Biological Sciences, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0003-1797-0591
Stella Martín-de-Las-HerasDepartamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0002-1554-951X
Fernando Rodríguez de FonsecaUnidad de Gestión Clínica de Salud Mental, IBIMA, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.ORCID 0000-0002-4516-5795
Julie A ChowenDepartment of Endocrinology, Instituto de Investigación Biomédica la Princesa, Hospital Infantil Universitario Niño Jesús, 28009 Madrid, Spain.
Jesús ArgenteDepartment of Endocrinology, Instituto de Investigación Biomédica la Princesa, Hospital Infantil Universitario Niño Jesús, 28009 Madrid, Spain.ORCID 0000-0001-5826-0276
Juan SuárezDepartamento de Anatomía Humana, Medicina Legal e Historia de la Ciencia, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, 29071 Málaga, Spain.ORCID 0000-0001-5254-9802
Hospital Regional Universitario de Málaga · ESInstituto de Investigación Biomédica de Málaga · ESMadrid Institute for Advanced Studies · ESSimon Fraser University · CA

Funding

Instituto de Salud Carlos III BFU2017-82565-C2-1-RInstituto de Salud Carlos III CP19/00068Instituto de Salud Carlos III CPII17/00024Instituto de Salud Carlos III PI16/00485Instituto de Salud Carlos III PI16/01374Instituto de Salud Carlos III PI19/00166Instituto de Salud Carlos III PI19/00343Natural Sciences and Engineering Research Council of Canada 2016-04047
6 · The paper itself

Abstract

Deficiency of pregnancy-associated plasma protein-A2 (PAPP-A2), an IGF-1 availability regulator, causes postnatal growth failure and dysregulation of bone size and density. The present study aimed to determine the effects of recombinant murine IGF-1 (rmIGF-1) on bone composition and remodeling in constitutive

Indexed as

AnimalsBone DensityBone RemodelingBone ResorptionCarrier ProteinsCollagen Type ICollagen Type I, alpha 1 ChainGene Expression Regulation, DevelopmentalHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiceMice, KnockoutOsteocalcinOsteogenesisOsteopontinCarrier ProteinsCollagen Type ICollagen Type I, alpha 1 ChainIGFBP3 protein, humanIGFBP5-interacting protein, mouseInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IOsteocalcinOsteopontinPAPPA2 protein, mousePregnancy-Associated Plasma Protein-AapatitebonecollagengrowthIGFBPPappa2 deficiencypappalysinsex difference

Identifiers

PMID33919940
PMCPMC8070906
OpenAlexW3156298789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.