Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium.

Franziska Dengler, Sofia Sova, Antti M Salo, Joni M Mäki, Peppi Koivunen, Johanna Myllyharju

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 64% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Franziska DenglerUnit of Physiology, Pathophysiology and Experimental Endocrinology, University of Veterinary Medicine, 1210 Vienna, Austria.ORCID 0000-0002-2178-2270

Sofia SovaFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.ORCID 0000-0001-5452-7922

Antti M SaloFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.

Joni M MäkiFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.

Peppi KoivunenFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.

Johanna MyllyharjuFaculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.

University of Oulu · FIUniversity of Veterinary Medicine Vienna · AT

Funding

Academy of Finland 296498Academy of Finland 308009European Molecular Biology Organization 7675Federation of European Biochemical Societies fellowshipJane ja Aatos Erkon SäätiöSigrid Juséliuksen Säätiö

6 · The paper itself

Abstract

The HIF prolyl 4-hydroxylases (HIF-P4H) control hypoxia-inducible factor (HIF), a powerful mechanism regulating cellular adaptation to decreased oxygenation. The gastrointestinal epithelium subsists in "physiological hypoxia" and should therefore have an especially well-designed control over this adaptation. Thus, we assessed the absolute mRNA expression levels of the HIF pathway components,

Indexed as

Gene Expression Regulation, EnzymologicAgingAnimalsCecumHypoxiaHypoxia-Inducible Factor-Proline DioxygenasesIntestinal MucosaIsoenzymesJejunumMiceMice, Inbred C57BLRNA, MessengerSignal TransductionHypoxia-Inducible Factor-Proline DioxygenasesIsoenzymesRNA, MessengercaecumcolonddPCRepitheliumHIFHIF-prolyl 4-hydroxylasejejunummRNA

Identifiers

PMID33919829

DOI10.3390/ijms22084038

PMCPMC8070794

OpenAlexW3154336083

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.