Evidence map›Paper›PMID 33919766›Full record

Observational studyNutrients2021

Lactose Intolerance Assessed by Analysis of Genetic Polymorphism, Breath Test and Symptoms in Patients with Inflammatory Bowel Disease.

Olga Maria Nardone, Francesco Manfellotto, Caterina D'Onofrio, Alba Rocco, Giovanni Annona, Francesca Sasso, Pasquale De Luca, Nicola Imperatore, Anna Testa, Roberto de Sire and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Observational
  3. Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025
    Review
  4. Review
  5. Observational
  6. Lactase deficiency in Russia: multiethnic genetic study.European journal of clinical nutrition · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Olga Maria NardoneGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.
Francesco ManfellottoSequencing and Molecular Analyses Center, RIMAR Department, Stazione Zoologica A. Dohrn, Villa Comunale, 80122 Naples, Italy.
Caterina D'OnofrioGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.
Alba RoccoGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.
Giovanni AnnonaSequencing and Molecular Analyses Center, RIMAR Department, Stazione Zoologica A. Dohrn, Villa Comunale, 80122 Naples, Italy.
Francesca SassoGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.ORCID 0000-0002-0251-6102
Pasquale De LucaSequencing and Molecular Analyses Center, RIMAR Department, Stazione Zoologica A. Dohrn, Villa Comunale, 80122 Naples, Italy.ORCID 0000-0003-4289-6784
Nicola ImperatoreGastroenterology and Endoscopy Unit, AORN Antonio Cardarelli, 80131 Naples, Italy.ORCID 0000-0003-3230-6832
Anna TestaGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.ORCID 0000-0002-4328-5267
Roberto de SireGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.
Elio BiffaliSequencing and Molecular Analyses Center, RIMAR Department, Stazione Zoologica A. Dohrn, Villa Comunale, 80122 Naples, Italy.
Fabiana CastiglioneGastroenterology, Department of Clinical Medicine and Surgery, University Federico II of Naples, 80131 Naples, Italy.
University of Naples Federico II · ITStazione Zoologica Anton Dohrn · ITOspedale Antonio Cardarelli · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many patients with inflammatory bowel disease (IBD) restrict dairy products to control their symptoms. The aim of the study was to investigate the prevalence of lactose intolerance assessed with hydrogen breath test (H-BT) in IBD patients in clinical remission compared to a sex, age and BMI matched control population. We further detected the prevalence of three single nucleotide polymorphisms of the lactase (LCT) gene: the lactase non persistence LCT-13910 CC (wildtype) and the intermediate phenotype LCT-22018 CT and LCT-13910 AG; finally, we assess the correlation between genotype and H-BT. A total of 54 IBD patients and 69 control who underwent clinical evaluation, H-BT and genetic test were enrolled. H-BT was positive in 64.8% IBD patients and 62.3% control (

Indexed as

AdultBreath TestsGenetic TestingHumansHydrogenInflammatory Bowel DiseasesLactaseLactoseLactose IntoleranceMaleMiddle AgedPolymorphism, Single NucleotidePrevalenceProspective StudiesYoung AdultHydrogenLactaseLactosehydrogen breath testinflammatory bowel diseaselactase polymorphismlactose intolerance

Identifiers

PMID33919766
PMCPMC8070715
OpenAlexW3154836544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.