Evidence map›Paper›PMID 33919527›Full record

ArticleInternational journal of molecular sciences2021

RNA Expression of DNA Damage Response Genes in Muscle-Invasive Bladder Cancer: Influence on Outcome and Response to Adjuvant Cisplatin-Based Chemotherapy.

Jonas Herrmann, Helena Schmidt, Katja Nitschke, Cleo-Aron Weis, Philipp Nuhn, Jost von Hardenberg, Maurice Stephan Michel, Philipp Erben, Thomas Stefan Worst

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Biomarkers for Early Detection of Cancer: Molecular Aspects.International journal of molecular sciences · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jonas HerrmannDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.ORCID 0000-0002-3358-946X
Helena SchmidtDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Katja NitschkeDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Cleo-Aron WeisInstitute for Pathology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Philipp NuhnDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Jost von HardenbergDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Maurice Stephan MichelDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
Philipp ErbenDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.ORCID 0000-0002-8279-7636
Thomas Stefan WorstDepartment of Urology, University Medical Centre Mannheim, 68167 Mannheim, Germany.
University Medical Centre Mannheim · DE

Funding

Monika Kutzner Stiftung no number given
6 · The paper itself

Abstract

backgroundPerioperative cisplatin-based chemotherapy (CBC) can improve the outcome of patients with muscle-invasive bladder cancer (MIBC), but it is still to be defined which patients benefit. Mutations in DNA damage response genes (DDRG) can predict the response to CBC. The value of DDRG expression as a marker of CBC treatment effect remains unclear. MATERIAL AND

methodsRNA expression of the nine key DDRG (

resultsLow expression of

conclusionLow expression of

Indexed as

AdultAgedAged, 80 and overAntineoplastic AgentsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinChemotherapy, AdjuvantCisplatinDNA DamageFemaleForkhead Box Protein M1HumansMaleMiddle AgedNeoplasm InvasivenessAntineoplastic AgentsBiomarkers, TumorBRCA1 ProteinBRCA2 ProteinCisplatinForkhead Box Protein M1adjuvant chemotherapyBCL2BRCA1BRCA2cisplatinDNA-damage responseERCC2ERCC6FOXM1muscle-invasive bladder cancerRAD50RAD51RAD52

Identifiers

PMID33919527
PMCPMC8073847
OpenAlexW3152875436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.