Evidence map›Paper›PMID 33919503›Full record

Trial reportNutrients2021

Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals.

Domenico Tricò, Diego Moriconi, Rossana Berta, Simona Baldi, Alfredo Quinones-Galvan, Letizia Guiducci, Stefano Taddei, Andrea Mari, Monica Nannipieri

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Domenico TricòDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7633-1346
Diego MoriconiDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy.
Rossana BertaBariatric Surgery Division, University Hospital of Pisa, 56124 Pisa, Italy.
Simona BaldiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Alfredo Quinones-GalvanFondazione Toscana Gabriele Monasterio, 56126 Pisa, Italy.
Letizia GuiducciInstitute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Stefano TaddeiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Andrea MariInstitute of Neuroscience, National Research Council, 35127 Padua, Italy.ORCID 0000-0002-1436-5591
Monica NannipieriDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-1346-2813
University of Pisa · ITAzienda Ospedaliera Universitaria Pisana · ITFondazione Toscana Gabriele Monasterio · ITIstituto di Fisiologia Clinica · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-calorie Mediterranean-style or low-carbohydrate dietary regimens are widely used nutritional strategies against obesity and associated metabolic diseases, including type 2 diabetes. The aim of this study was to compare the effectiveness of a balanced Mediterranean diet with a low-carbohydrate diet on weight loss and glucose homeostasis in morbidly obese individuals at high risk to develop diabetes. Insulin secretion, insulin clearance, and different β-cell function components were estimated by modeling plasma glucose, insulin and C-peptide profiles during 75-g oral glucose tolerance tests (OGTTs) performed at baseline and after 4 weeks of each dietary intervention. The average weight loss was 5%, being 58% greater in the low-carbohydrate-group than Mediterranean-group. Fasting plasma glucose and glucose tolerance were not affected by the diets. The two dietary regimens proved similarly effective in improving insulin resistance and fasting hyperinsulinemia, while enhancing endogenous insulin clearance and β-cell glucose sensitivity. In summary, we demonstrated that a low-carbohydrate diet is a successful short-term approach for weight loss in morbidly obese patients and a feasible alternative to the Mediterranean diet for its glucometabolic benefits, including improvements in insulin resistance, insulin clearance and β-cell function. Further studies are needed to compare the long-term efficacy and safety of the two diets.

Indexed as

Diet, MediterraneanWeight LossAdultBlood GlucoseDiet, Carbohydrate-RestrictedDiet, ReducingFastingFemaleGlucose Tolerance TestHumansInsulinInsulin ResistanceInsulin-Secreting CellsMaleMiddle AgedObesity, MorbidBlood GlucoseInsulinbeta cell functionglucose tolerancehigh protein dietinsulin clearanceinsulin secretioninsulin sensitivityMediterranean dietobesityweight loss intervention

Identifiers

PMID33919503
PMCPMC8074206
OpenAlexW3156017178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.