Evidence map›Paper›PMID 33919396›Full record

ArticleInternational journal of molecular sciences2021

Rational Design of Resveratrol O-methyltransferase for the Production of Pinostilbene.

Daniela P Herrera, Andrea M Chánique, Ascensión Martínez-Márquez, Roque Bru-Martínez, Robert Kourist, Loreto P Parra, Andreas Schüller

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Daniela P HerreraDepartment of Chemical and Bioprocesses Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820244, Chile.ORCID 0000-0003-4465-6522
Andrea M ChániqueDepartment of Chemical and Bioprocesses Engineering, School of Engineering, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820244, Chile.ORCID 0000-0003-0642-1351
Ascensión Martínez-MárquezDepartment of Agrochemistry and Biochemistry, Faculty of Science and Multidisciplinary Institute for Environmental Studies "Ramon Margalef", University of Alicante, 03690 Alicante, Spain.ORCID 0000-0002-2853-3525
Roque Bru-MartínezDepartment of Agrochemistry and Biochemistry, Faculty of Science and Multidisciplinary Institute for Environmental Studies "Ramon Margalef", University of Alicante, 03690 Alicante, Spain.
Robert KouristInstitute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria.
Loreto P ParraInstitute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820244, Chile.
Andreas SchüllerInstitute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860, Santiago 7820244, Chile.ORCID 0000-0002-4443-4279
Pontificia Universidad Católica de Chile · CLInstitute of Molecular Biotechnology · ATUniversity of Alicante · ES

Funding

Agencia Nacional de Investigación y Desarrollo, Chile BECA DE DOCTORADO NACIONAL No. 21161084Pontificia Universidad Católica de Chile PROYECTO INTERDISCIPLINA VRI UC No. II160020
6 · The paper itself

Abstract

Pinostilbene is a monomethyl ether analog of the well-known nutraceutical resveratrol. Both compounds have health-promoting properties, but the latter undergoes rapid metabolization and has low bioavailability. O-methylation improves the stability and bioavailability of resveratrol. In plants, these reactions are performed by O-methyltransferases (OMTs). Few efficient OMTs that monomethylate resveratrol to yield pinostilbene have been described so far. Here, we report the engineering of a resveratrol OMT from

Indexed as

Metabolic EngineeringMethyltransferasesModels, MolecularPhylogenyPlant ProteinsProtein ConformationRecombinant ProteinsResveratrolStilbenesVitisMethyltransferasespinostilbenePlant ProteinsRecombinant ProteinsResveratrolStilbenesenzyme engineeringO-methyltransferasespinostilbeneprotein modelsstilbenessubstrate selectivity

Identifiers

PMID33919396
PMCPMC8122247
OpenAlexW3154916411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.