Observational studyInternational journal of environmental research and public health2021
Changes in Multimorbidity and Polypharmacy Patterns in Young and Adult Population over a 4-Year Period: A 2011-2015 Comparison Using Real-World Data.
Observational study in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of disease clusters in multimorbidity.Nature communications · 2025Pooled it
- Mapping medication adherence interventions across Europe: Expert perspectives from 35 countries.Public health in practice (Oxford, England) · 2026Article
- Supporting complex mental health care and services research today and beyond: a mini-review of real-world evidence strategies and informed approaches.Frontiers in health services · 2026Review
- Multimorbidity in Focus: Emerging Patterns, Medication Appropriateness and Clinical Innovation.Journal of clinical medicine · 2025Article
- Challenge of long-term benzodiazepine use in primary care: insights from a real-world cohort study in Catalonia.Family medicine and community health · 2025Article
- The Aging Lung: Exploring Multimorbidity Patterns and Their Clinical Implications: A Narrative Review.Current issues in molecular biology · 2025Review
- Change in Stress Among Individuals with Chronic Health Conditions and Low Health Literacy Using a Tailored Communication App Promoting Self-Management.Behavioral sciences (Basel, Switzerland) · 2025Article
- Effects of Primary Healthcare Quality and Effectiveness on Hospitalization Indicators in Brazil.Journal of market access & health policy · 2025Article
- Electronic Health Records: A Gateway to AI-Driven Multimorbidity Solutions-A Comprehensive Systematic Review.Journal of clinical medicine · 2025Review
- Assessment of Medication Adherence Using Mobile Applications in Chronic Obstructive Pulmonary Disease: A Scoping Review.International journal of environmental research and public health · 2024Article
- Haemodynamic Forces: Emerging Markers of Ventricular Remodelling in Multiple Myeloma Cardiovascular Baseline Risk Assessment.Cancers · 2024Article
- Multimorbidity patterns and trajectories in young and middle-aged adults: a large-scale population-based cohort study.Frontiers in public health · 2024Article
- Pharmacological and Nutritional Modulation of Metabolome and Metagenome in Cardiometabolic Disorders.Biomolecules · 2023Review
- Reports of Symptoms Associated with Supraventricular Arrhythmias as a Serious Adverse Drug Reaction in the Spanish Pharmacovigilance Database.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort.International journal of environmental research and public health · 2022Article
- Exploring Patient Multimorbidity and Complexity Using Health Insurance Claims Data: A Cluster Analysis Approach.JMIR medical informatics · 2022Article
- Trends in the Prescription of Benzodiazepine Receptor Agonists from 2009 to 2020: A Retrospective Study Using Electronic Healthcare Record Data of a University Hospital in Japan.Healthcare (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pressing problem of multimorbidity and polypharmacy is aggravated by the lack of specific care models for this population. We aimed to investigate the evolution of multimorbidity and polypharmacy patterns in a given population over a 4-year period (2011-2015). A cross-sectional, observational study among the EpiChron Cohort, including anonymized demographic, clinical and drug dispensation information of all users of the public health system ≥65 years in Aragon (Spain), was performed. An exploratory factor analysis, stratified by age and sex, using an open cohort was carried out based on the tetra-choric correlations among chronic diseases and dispensed drugs during 2011 and compared with 2015. Seven baseline patterns were identified during 2011 named as: mental health, respiratory, allergic, mechanical pain, cardiometabolic, osteometabolic, and allergic/derma. Of the epidemiological patterns identified in 2015, six were already present in 2011 but a new allergic/derma one appeared. Patterns identified in 2011 were more complex in terms of both disease and drugs. Results confirmed the existing association between age and clinical complexity. The systematic associations between diseases and drugs remain similar regarding their clinical nature over time, helping in early identification of potential interactions in multimorbid patients with a high risk of negative health outcomes due to polypharmacy.
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